HitPredict

Interactor 1: WASL (O00401)
Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP)
Gene: WASL

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15834156
Identification Methods	coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0015629 - actin cytoskeleton and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 505 Hs			1 304
+	Dm
		1361430 Q9VAT0_DROME (1-504): 8.78e-57: 199: 31.37		CRK_DROME (5-302): 8.8e-52: 173: 43.14
+	Hs
		790644 WASP_HUMAN (16-313): 7.4e-38: 147: 44.41		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		203218 SYNJ1_HUMAN (4-500): 4.14e-62: 222: 14.85		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		166042 SYNJ2_HUMAN (3-471): 6.56e-60: 215: 14.85		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		203208 SYNJ1_HUMAN (4-500): 4.14e-62: 222: 14.85		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		203228 SYNJ1_HUMAN (4-500): 4.14e-62: 222: 14.85		ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87
+	Hs
		203241 SYNJ1_HUMAN (4-500): 4.14e-62: 222: 14.85		SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22
+	Hs
		166056 SYNJ2_HUMAN (3-471): 6.56e-60: 215: 14.85		ITSN2_HUMAN (189-304): 5.82e-12: 68.3: 11.86
+	Hs
		166060 SYNJ2_HUMAN (3-471): 6.56e-60: 215: 14.85		CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12
+	Hs
		166030 SYNJ2_HUMAN (3-471): 6.56e-60: 215: 14.85		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		166049 SYNJ2_HUMAN (3-471): 6.56e-60: 215: 14.85		ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87
+	Hs
		166055 SYNJ2_HUMAN (3-471): 6.56e-60: 215: 14.85		SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22
+	Hs
		580954 WASP_HUMAN (16-313): 7.4e-38: 147: 44.41		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		790657 WASP_HUMAN (16-313): 7.4e-38: 147: 44.41		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Ce
		666212 Q17795_CAEEL (1-457): 4.87e-36: 143: 27.14		SEM5_CAEEL (135-291): 6.58e-25: 101: 14.83
+	Mm
		936473 WASP_MOUSE (16-487): 4.45e-46: 170: 39.21		NCK1_MOUSE (2-100): 1.35e-10: 63.3: 18.00
+	Hs
		790688 WASP_HUMAN (16-313): 7.4e-38: 147: 44.41		ITSN2_HUMAN (189-304): 5.82e-12: 68.3: 11.86
+	Hs
		209002 WASP_HUMAN (16-313): 7.4e-38: 147: 44.41		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		557631 WASP_HUMAN (16-313): 7.4e-38: 147: 44.41		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		790676 WASP_HUMAN (16-313): 7.4e-38: 147: 44.41		ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87