HitPredict

Interactor 1: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Interactor 2: SMCE1 (Q969G3)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57)
Gene: SMARCE1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	29509190, 12145209
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 530 Hs			1 411
+	Hs
		370155 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		SMCE1_HUMAN (1-411): 6.03e-79: 251: 100.00
+	Mm
		222663 ESR1_MOUSE (9-529): 4.88e-134: 403: 43.72		SMCE1_MOUSE (1-411): 4.03e-78: 249: 97.32
+	Hs
		1269686 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		HM20A_HUMAN (3-308): 1.64e-39: 146: 16.08
+	Hs
		500373 RARB_HUMAN (49-529): 1.02e-113: 346: 23.92		SMCE1_HUMAN (1-411): 6.03e-79: 251: 100.00
+	Hs
		782620 HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30		SMCE1_HUMAN (1-411): 6.03e-79: 251: 100.00
+	Hs
		377561 GCR_HUMAN (3-495): 1.12e-103: 330: 22.64		SMCE1_HUMAN (1-411): 6.03e-79: 251: 100.00
+	Hs
		370598 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		HM20B_HUMAN (37-302): 3.88e-47: 165: 20.51
+	Mm
		222660 NR4A1_MOUSE (7-501): 1.18e-103: 325: 25.35		SMCE1_MOUSE (1-411): 4.03e-78: 249: 97.32
+	Hs
		611485 NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30		SMCE1_HUMAN (1-411): 6.03e-79: 251: 100.00
+	Hs
		368940 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		UBF1_HUMAN (55-380): 1.54e-40: 155: 14.99
+	Hs
		370492 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		HM20A_HUMAN (3-308): 1.64e-39: 146: 16.08
+	Hs
		369409 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		TFAM_HUMAN (64-259): 2.52e-29: 116: 19.19
+	Hs
		369480 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		SSRP1_HUMAN (61-135): 1.2e-21: 99.3: 25.33
+	Hs
		782676 HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30		HM20B_HUMAN (37-302): 3.88e-47: 165: 20.51
+	Hs
		313685 GCR_HUMAN (3-495): 1.12e-103: 330: 22.64		SOX14_HUMAN (61-209): 3.78e-35: 131: 17.45
+	Hs
		414521 PRGR_HUMAN (149-459): 2.26e-41: 161: 32.82		SMCE1_HUMAN (1-411): 6.03e-79: 251: 100.00
+	Hs
		487652 ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59		SMCE1_HUMAN (1-411): 6.03e-79: 251: 100.00
+	Hs
		487801 ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59		HM20B_HUMAN (37-302): 3.88e-47: 165: 20.51
+	Hs
		487108 ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59		UBF1_HUMAN (55-380): 1.54e-40: 155: 14.99
+	Hs
		487373 ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59		SSRP1_HUMAN (61-135): 1.2e-21: 99.3: 25.33