HitPredict

Interactor 1: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Interactor 2: P121A (Q96HA1)
Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa)
Gene: POM121

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	21182203
Identification Methods	cosedimentation through density gradient
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 530 Hs			1 1249
+	Hs
		65044 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		P121C_HUMAN (1-1249): 1.9e-77: 282: 93.93
+	Hs
		554348 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		MUC1_HUMAN (245-1245): 7.09e-53: 205: 12.49
+	Hs
		368927 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		MUC1_HUMAN (245-1245): 7.09e-53: 205: 12.49
+	Hs
		1269607 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		WNK1_HUMAN (36-1241): 1.45e-32: 140: 10.65
+	Hs
		1270066 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		PCLO_HUMAN (1-957): 4.88e-24: 112: 8.71
+	Hs
		858022 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		NUP98_HUMAN (828-1223): 9.68e-19: 95.1: 19.77
+	Hs
		727299 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		NU214_HUMAN (91-1211): 3.61e-15: 83.5: 12.90
+	Hs
		1243831 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		KMT2C_HUMAN (570-1226): 5.4e-15: 82.9: 13.37
+	Hs
		1270028 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		PRC2C_HUMAN (2-1138): 9.15e-15: 82.1: 9.62
+	Hs
		1269843 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		YM012_HUMAN (734-1234): 1.51e-14: 80.4: 14.72
+	Hs
		1056909 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		MDC1_HUMAN (87-1249): 8.98e-14: 78.8: 9.17
+	Hs
		1057780 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		NCOA6_HUMAN (362-1248): 1.45e-11: 71.5: 8.61
+	Hs
		1269413 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		CIC_HUMAN (128-1161): 2.11e-09: 64.5: 9.81
+	Hs
		1269948 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		SRRM2_HUMAN (3-891): 8.36e-09: 62.5: 10.62
+	Hs
		370040 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		KMT2C_HUMAN (570-1226): 5.4e-15: 82.9: 13.37
+	Hs
		369607 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		MDC1_HUMAN (87-1249): 8.98e-14: 78.8: 9.17
+	Hs
		369612 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		NCOA6_HUMAN (362-1248): 1.45e-11: 71.5: 8.61
+	Hs
		370251 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		CIC_HUMAN (128-1161): 2.11e-09: 64.5: 9.81
+	Hs
		370728 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		SRRM2_HUMAN (3-891): 8.36e-09: 62.5: 10.62
+	Hs
		587169 RXRA_HUMAN (13-502): 1.6e-119: 361: 25.71		NCOA6_HUMAN (362-1248): 1.45e-11: 71.5: 8.61