HitPredict

Interactor 1: WASL (O00401)
Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP)
Gene: WASL

Interactor 2: DNMBP (Q6XZF7)
Dynamin-binding protein (Scaffold protein Tuba)
Gene: DNMBP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	14506234, 24332715
Identification Methods	affinity chromatography technology, x-ray crystallography, isothermal titration calorimetry
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 505 Hs			1 1577
+	Rn
		139991 SYNJ1_RAT (4-505): 7.74e-69: 241: 13.31		BIN1_RAT (994-1575): 5.76e-74: 260: 15.91
+	Hs
		131177 SYNJ2_HUMAN (3-471): 6.56e-60: 215: 14.85		BIN1_HUMAN (994-1574): 3.96e-74: 261: 16.98
+	Rn
		139978 SYNJ1_RAT (4-505): 7.74e-69: 241: 13.31		AMPH_RAT (995-1361): 1.7e-63: 232: 19.16
+	Mm
		139043 WASL_MOUSE (379-485): 1.86e-30: 125: 95.33		BIN1_MOUSE (994-1575): 1.88e-75: 265: 16.06
+	Hs
		126878 WASL_HUMAN (378-485): 2.86e-29: 122: 100.00		BIN1_HUMAN (994-1574): 3.96e-74: 261: 16.98
+	Hs
		203230 SYNJ1_HUMAN (4-500): 4.14e-62: 222: 14.85		SH319_HUMAN (3-127): 1.19e-14: 81.4: 24.62
+	Hs
		203241 SYNJ1_HUMAN (4-500): 4.14e-62: 222: 14.85		SH3K1_HUMAN (158-324): 3.67e-12: 73.2: 28.09
+	Hs
		203228 SYNJ1_HUMAN (4-500): 4.14e-62: 222: 14.85		ITSN1_HUMAN (6-104): 1.33e-11: 72.1: 19.19
+	Hs
		166056 SYNJ2_HUMAN (3-471): 6.56e-60: 215: 14.85		ITSN2_HUMAN (2-104): 1.6e-13: 78.2: 20.39
+	Hs
		166055 SYNJ2_HUMAN (3-471): 6.56e-60: 215: 14.85		SH3K1_HUMAN (158-324): 3.67e-12: 73.2: 28.09
+	Hs
		166049 SYNJ2_HUMAN (3-471): 6.56e-60: 215: 14.85		ITSN1_HUMAN (6-104): 1.33e-11: 72.1: 19.19
+	Dm
		112580 Q9VAT0_DROME (1-504): 8.78e-57: 199: 31.37		M9ND00_DROME (1-139): 5.25e-13: 76.4: 18.79
+	Dm
		1361426 Q9VAT0_DROME (1-504): 8.78e-57: 199: 31.37		Q9VIF7_DROME (1-121): 1.89e-12: 74.5: 20.41
+	Hs
		790688 WASP_HUMAN (16-313): 7.4e-38: 147: 44.41		ITSN2_HUMAN (2-104): 1.6e-13: 78.2: 20.39
+	Hs
		790676 WASP_HUMAN (16-313): 7.4e-38: 147: 44.41		ITSN1_HUMAN (6-104): 1.33e-11: 72.1: 19.19
+	Ce
		105229 Q17795_CAEEL (1-457): 4.87e-36: 143: 27.14		G5ECK4_CAEEL (140-528): 5.95e-10: 66.5: 14.04
+	Hs
		126965 WASL_HUMAN (378-485): 2.86e-29: 122: 100.00		ITSN2_HUMAN (2-104): 1.6e-13: 78.2: 20.39
+	Hs
		126950 WASL_HUMAN (378-485): 2.86e-29: 122: 100.00		SH3K1_HUMAN (158-324): 3.67e-12: 73.2: 28.09
+	Hs
		126936 WASL_HUMAN (378-485): 2.86e-29: 122: 100.00		ITSN1_HUMAN (6-104): 1.33e-11: 72.1: 19.19
+	Rn
		94091 F1LSG0_RAT (379-485): 2.85e-30: 125: 95.33		ITSN1_RAT (6-104): 9.79e-11: 69: 19.19