HitPredict

Interactor 1: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Interactor 2: SIN3A (Q96ST3)
Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)
Gene: SIN3A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	29509190, 21182203
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 530 Hs			1 1273
+	Hs
		370261 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		SIN3A_HUMAN (1-1273): 0: 1545: 100.00
+	Hs
		795604 NR4A2_HUMAN (23-501): 3.24e-98: 311: 23.30		SIN3A_HUMAN (1-1273): 0: 1545: 100.00
+	Hs
		487701 ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59		SIN3A_HUMAN (1-1273): 0: 1545: 100.00
+	Hs
		257814 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15
+	Hs
		257735 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15
+	Hs
		257740 ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15