HitPredict

Interactor 1: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Interactor 2: PHB2 (Q99623)
Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity)
Gene: PHB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29509190, 36223738
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0030520 - estrogen receptor signaling pathway GO:0051091 - positive regulation of DNA-binding transcription factor activity
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 530 Hs			1 299
+	Hs
		370282 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00
+	Hs
		719033 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		PHB1_HUMAN (22-280): 1e-85: 259: 51.15
+	Hs
		646250 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		STOM_HUMAN (1-286): 2.42e-84: 256: 17.93
+	Hs
		369087 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		PHB1_HUMAN (22-280): 1e-85: 259: 51.15
+	Hs
		369022 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		STOM_HUMAN (1-286): 2.42e-84: 256: 17.93
+	Hs
		320222 ERR2_HUMAN (69-499): 5.86e-109: 333: 31.57		PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00
+	Hs
		490112 COT1_HUMAN (83-502): 2.36e-106: 326: 23.88		PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00
+	Hs
		622828 COT2_HUMAN (77-502): 2.24e-102: 316: 23.90		PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00
+	Hs
		320178 ERR2_HUMAN (69-499): 5.86e-109: 333: 31.57		PHB1_HUMAN (22-280): 1e-85: 259: 51.15
+	Hs
		487710 ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59		PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00
+	Hs
		487181 ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59		PHB1_HUMAN (22-280): 1e-85: 259: 51.15