HitPredict

Interactor 1: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Interactor 2: BRD8 (Q9H0E9)
Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120)
Gene: BRD8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	21182203
Identification Methods	affinity chromatography technology
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005739 - mitochondrion GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 530 Hs			1 1235
+	Hs
		370401 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		BRD8_HUMAN (1-1235): 0: 594: 100.00
+	Hs
		1017331 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		BPTF_HUMAN (130-1222): 5.45e-42: 171: 9.55
+	Hs
		1269940 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		TRI33_HUMAN (820-1232): 7.65e-33: 140: 11.56
+	Hs
		170435 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		TIF1A_HUMAN (845-1228): 4.33e-31: 134: 14.07
+	Hs
		1269694 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		BRD7_HUMAN (1005-1212): 3.07e-29: 127: 15.02
+	Hs
		998934 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		EP300_HUMAN (807-1211): 2.38e-27: 123: 13.66
+	Hs
		1199171 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		PB1_HUMAN (987-1226): 1.89e-22: 107: 15.45
+	Hs
		847036 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		SMCA4_HUMAN (1057-1208): 7.26e-19: 95.5: 13.84
+	Hs
		370719 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		TRI33_HUMAN (820-1232): 7.65e-33: 140: 11.56
+	Hs
		170202 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		TIF1A_HUMAN (845-1228): 4.33e-31: 134: 14.07
+	Hs
		370655 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		BAZ2A_HUMAN (125-815): 2.72e-30: 132: 10.85
+	Hs
		370499 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		BRD7_HUMAN (1005-1212): 3.07e-29: 127: 15.02
+	Hs
		369484 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		EP300_HUMAN (807-1211): 2.38e-27: 123: 13.66
+	Hs
		1269279 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		KAT2A_HUMAN (684-810): 1.1e-12: 74.9: 17.32
+	Hs
		1269276 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		CBP_HUMAN (125-595): 9.03e-09: 62.2: 12.22
+	Hs
		369920 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		PB1_HUMAN (987-1226): 1.89e-22: 107: 15.45
+	Hs
		369975 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		TAF1L_HUMAN (1101-1206): 4.22e-19: 96.3: 21.70
+	Hs
		369214 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		SMCA4_HUMAN (1057-1208): 7.26e-19: 95.5: 13.84
+	Hs
		370140 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		KAT2A_HUMAN (684-810): 1.1e-12: 74.9: 17.32
+	Hs
		370136 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		CBP_HUMAN (125-595): 9.03e-09: 62.2: 12.22