HitPredict

Interactor 1: WASL (O00401)
Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP)
Gene: WASL

Interactor 2: PACN2 (Q9UNF0)
Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII)
Gene: PACSIN2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.658

Property	Details
Experiments	32296183, 11082044, unassigned1304
Identification Methods	two hybrid, pull down, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070062 - extracellular exosome GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 505 Hs			1 486
+	Hs
		203262 SYNJ1_HUMAN (4-500): 4.14e-62: 222: 14.85		PACN2_HUMAN (1-486): 1.94e-100: 311: 100.00
+	Hs
		203251 SYNJ1_HUMAN (4-500): 4.14e-62: 222: 14.85		PACN1_HUMAN (1-485): 3.17e-82: 263: 61.73
+	Dm
		1361424 Q9VAT0_DROME (1-504): 8.78e-57: 199: 31.37		Q9VDI1_DROME (1-483): 7.88e-86: 274: 42.94
+	Hs
		790694 WASP_HUMAN (16-313): 7.4e-38: 147: 44.41		PACN2_HUMAN (1-486): 1.94e-100: 311: 100.00
+	Hs
		203260 SYNJ1_HUMAN (4-500): 4.14e-62: 222: 14.85		PACN3_HUMAN (6-485): 8.44e-67: 222: 41.04
+	Hs
		790686 WASP_HUMAN (16-313): 7.4e-38: 147: 44.41		PACN1_HUMAN (1-485): 3.17e-82: 263: 61.73
+	Hs
		203224 SYNJ1_HUMAN (4-500): 4.14e-62: 222: 14.85		MYO1E_HUMAN (9-485): 6.43e-38: 149: 13.04
+	Hs
		790693 WASP_HUMAN (16-313): 7.4e-38: 147: 44.41		PACN3_HUMAN (6-485): 8.44e-67: 222: 41.04
+	Dm
		112684 Q9VAT0_DROME (1-504): 8.78e-57: 199: 31.37		M9NE16_DROME (2-435): 2.79e-44: 166: 13.04
+	Dm
		1361429 Q9VAT0_DROME (1-504): 8.78e-57: 199: 31.37		Q9VZD7_DROME (2-435): 1.6e-43: 164: 13.04
+	Mm
		936465 WASP_MOUSE (16-487): 4.45e-46: 170: 39.21		PPIP1_MOUSE (9-485): 3.28e-54: 189: 18.05
+	Hs
		207777 WASP_HUMAN (16-313): 7.4e-38: 147: 44.41		PPIP1_HUMAN (9-485): 2.02e-55: 192: 18.67
+	Mm
		936466 WASP_MOUSE (16-487): 4.45e-46: 170: 39.21		Q0VBR8_MOUSE (16-299): 3.97e-43: 159: 17.01
+	Hs
		790675 WASP_HUMAN (16-313): 7.4e-38: 147: 44.41		CIP4_HUMAN (12-465): 9.47e-47: 173: 15.03
+	Ce
		1089142 Q17795_CAEEL (1-457): 4.87e-36: 143: 27.14		Q18501_CAEEL (7-482): 1.47e-44: 166: 14.02
+	Hs
		790685 WASP_HUMAN (16-313): 7.4e-38: 147: 44.41		FNBP1_HUMAN (12-397): 7.86e-42: 159: 15.01
+	Hs
		790671 WASP_HUMAN (16-313): 7.4e-38: 147: 44.41		SRC8_HUMAN (47-484): 5.84e-38: 147: 11.40
+	Dm
		1361428 Q9VAT0_DROME (1-504): 8.78e-57: 199: 31.37		DBNL_DROME (334-485): 6.1e-11: 66.5: 26.62
+	Hs
		297961 WASP_HUMAN (16-313): 7.4e-38: 147: 44.41		FCSD2_HUMAN (38-485): 6.87e-12: 69.8: 13.81
+	Hs
		242926 WASP_HUMAN (16-313): 7.4e-38: 147: 44.41		GAS7_HUMAN (427-486): 7.06e-09: 59.9: 34.43