Interactor 1: PDE2A (O00408)
cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)
Gene: PDE2A

Interactor 2: PDE2A (O00408)
cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)
Gene: PDE2A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.64 1.00 0.802

The method score is based on:

Property Details
Experiments 33087821, 19828435
Identification Methods affinity chromatography technology, x-ray crystallography, molecular sieving, light scattering
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains GAF~GAF, GAF~PDEase_I, PDEase_I~PDEase_I
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000287 - magnesium ion binding
GO:0003170 - heart valve development
GO:0003281 - ventricular septum development
GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity
and 45 others

more...

Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 941
Hs

1 941
+ Hs
+ Hs
+ Hs
+ Hs
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+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024