HitPredict

Interactor 1: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Interactor 2: SI1L2 (Q9P2F8)
Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2)
Gene: SIPA1L2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.50	0.521

Property	Details
Experiments	29509190, 21182203
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 530 Hs			1 1722
+	Hs
		196487 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		SI1L1_HUMAN (1-1719): 0: 1424: 48.02
+	Hs
		196393 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		SI1L1_HUMAN (1-1719): 0: 1424: 48.02
+	Hs
		230266 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		SI1L3_HUMAN (19-1714): 0: 1313: 42.85
+	Hs
		230194 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		SI1L3_HUMAN (19-1714): 0: 1313: 42.85
+	Hs
		1102433 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		RGPA2_HUMAN (502-852): 1.14e-101: 364: 21.63
+	Hs
		369199 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		TSC2_HUMAN (538-860): 1.95e-102: 367: 21.07
+	Rn
		411259 ESR1_RAT (9-529): 1.16e-129: 392: 43.29		TSC2_RAT (538-860): 7.73e-102: 365: 19.10
+	Hs
		1270066 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		PCLO_HUMAN (1043-1712): 2.32e-13: 78.1: 8.16
+	Hs
		1243831 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		KMT2C_HUMAN (1268-1672): 1.15e-09: 65.8: 10.19
+	Hs
		370190 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		SIPA1_HUMAN (1389-1707): 1.51e-20: 101: 18.71
+	Hs
		370040 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		KMT2C_HUMAN (1268-1672): 1.15e-09: 65.8: 10.19
+	Mm
		101423 ESR1_MOUSE (9-529): 4.88e-134: 403: 43.72		F8VPR5_MOUSE (1126-1630): 1.63e-11: 72: 9.73
+	Mm
		101427 RXRG_MOUSE (13-499): 5.3e-117: 355: 22.56		F8VPR5_MOUSE (1126-1630): 1.63e-11: 72: 9.73
+	Hs
		782595 HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30		KMT2C_HUMAN (1268-1672): 1.15e-09: 65.8: 10.19
+	Mm
		101828 ERR2_MOUSE (69-499): 5.26e-107: 328: 31.11		F8WI37_MOUSE (1059-1646): 1.46e-09: 65.8: 7.93
+	Mm
		1142676 ERR2_MOUSE (69-499): 5.26e-107: 328: 31.11		KMT2C_MOUSE (1059-1646): 1.46e-09: 65.8: 7.93
+	Hs
		487596 ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59		KMT2C_HUMAN (1268-1672): 1.15e-09: 65.8: 10.19