HitPredict

Interactor 1: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Interactor 2: MED23 (Q9ULK4)
Mediator of RNA polymerase II transcription subunit 23 (Activator-recruited cofactor 130 kDa component) (ARC130) (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (hSur-2) (Transcriptional coactivator CRSP130) (Vitamin D3 receptor-interacting protein complex 130 kDa component) (DRIP130)
Gene: MED23

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.641

Property	Details
Experiments	29509190, 11867769, 21182203
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006355 - regulation of DNA-templated transcription GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 530 Hs			1 1368
+	Hs
		370690 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		MED23_HUMAN (1-1368): 0: 2164: 100.00
+	Hs
		782691 HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30		MED23_HUMAN (1-1368): 0: 2164: 100.00
+	Mm
		1142670 ERR2_MOUSE (69-499): 5.26e-107: 328: 31.11		MED23_MOUSE (1-1368): 0: 2083: 96.27
+	Hs
		487833 ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59		MED23_HUMAN (1-1368): 0: 2164: 100.00