HitPredict

Interactor 1: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Interactor 2: NCOA3 (Q9Y6Q9)
Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)
Gene: NCOA3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.964

The method score is based on:

Property Details
Experiments 11389589, 10681591, 17158759, 11500849, 12554772, 11376110, 9765300, 21182203
Identification Methods pull down, affinity chromatography technology, fluorescent resonance energy transfer, unspecified method, two hybrid, cosedimentation through density gradient
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains DUF4927~Hormone_recep, Hormone_recep~SRC-1
Common GO terms GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0045944 - positive regulation of transcription by RNA polymerase II
GO:0071392 - cellular response to estradiol stimulus
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Last updated: 15 Jul 2024