HitPredict

Interactor 1: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Interactor 2: PIAS3 (Q9Y6X2)
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)
Gene: PIAS3

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29509190, 11117529
Identification Methods	affinity chromatography technology, biochemical
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 530 Hs			1 628
+	Hs
		370843 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		611538 NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		278138 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		277875 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278312 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		278206 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		277974 HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		277876 GCR_HUMAN (3-495): 1.12e-103: 330: 22.64		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278072 NR1H3_HUMAN (65-499): 1.77e-104: 322: 20.97		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278004 NR1H2_HUMAN (49-499): 2.78e-103: 319: 20.86		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		277936 NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		414536 PRGR_HUMAN (149-459): 2.26e-41: 161: 32.82		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		278207 GCR_HUMAN (3-495): 1.12e-103: 330: 22.64		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		278228 NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		277885 PRGR_HUMAN (149-459): 2.26e-41: 161: 32.82		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		277899 ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		510028 ERR1_HUMAN (85-497): 1.88e-112: 342: 35.65		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71
+	Hs
		782594 HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71
+	Hs
		278210 PRGR_HUMAN (149-459): 2.26e-41: 161: 32.82		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		278213 ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59		PIAS2_HUMAN (1-550): 0: 651: 59.00