Interactor 1: RYR2 (Q92736)
Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor)
Gene: RYR2

Interactor 2: RYR2 (Q92736)
Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor)
Gene: RYR2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 21262961, 25411383, 14722100
Identification Methods fluorescent resonance energy transfer, two hybrid, affinity chromatography technology, pull down
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains EF-hand_7~EF-hand_7, EF-hand_7~Ion_trans, Ins145_P3_rec~Ins145_P3_rec, Ins145_P3_rec~MIR, Ins145_P3_rec~RIH_assoc, Ins145_P3_rec~RYDR_ITPR, Ion_trans~Ion_trans, Ion_trans~RR_TM4-6, MIR~MIR, MIR~RYDR_ITPR, RR_TM4-6~RR_TM4-6, RYDR_ITPR~RYDR_ITPR, RYDR_ITPR~SPRY, RyR~RyR, RyR~SPRY, SPRY~SPRY
Common GO terms GO:0001666 - response to hypoxia
GO:0002027 - regulation of heart rate
GO:0003143 - embryonic heart tube morphogenesis
GO:0003220 - left ventricular cardiac muscle tissue morphogenesis
GO:0003300 - cardiac muscle hypertrophy
and 55 others

more...

Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 4967
Hs

1 4967
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Oc
+ Oc
+ Hs
+ Hs
+ Mm
+ Rn
+ Hs
+ Ce
+ Dm
+ Hs
+ Hs

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Last updated: 15 Jul 2024