HitPredict

Interactor 1: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Interactor 2: H2B1A (Q96A08)
Histone H2B type 1-A (Histone H2B, testis) (TSH2B.1) (hTSH2B) (Testis-specific histone H2B)
Gene: H2BC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.670

Property	Details
Experiments	24722339, 28514442, 33961781
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0042393 - histone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 488 Hs			1 127
+	Hs
		1270408 HDAC2_HUMAN (1-488): 0: 707: 100.00		H2B1M_HUMAN (1-127): 6.74e-55: 169: 84.25
+	Hs
		1087306 HDAC2_HUMAN (1-488): 0: 707: 100.00		H2B2E_HUMAN (1-127): 4.39e-54: 167: 85.83
+	Hs
		707699 HDAC2_HUMAN (1-488): 0: 707: 100.00		H2B1B_HUMAN (1-127): 6.87e-54: 166: 85.83
+	Hs
		1270409 HDAC2_HUMAN (1-488): 0: 707: 100.00		H2B1L_HUMAN (1-127): 1.35e-52: 163: 85.83
+	Hs
		1231218 HDAC2_HUMAN (1-488): 0: 707: 100.00		H2B3B_HUMAN (1-127): 8.98e-51: 158: 85.83
+	Hs
		1038424 HDAC1_HUMAN (1-443): 0: 642: 90.07		H2B2E_HUMAN (1-127): 4.39e-54: 167: 85.83
+	Hs
		707620 HDAC1_HUMAN (1-443): 0: 642: 90.07		H2B1B_HUMAN (1-127): 6.87e-54: 166: 85.83
+	Hs
		918340 HDAC1_HUMAN (1-443): 0: 642: 90.07		H2B1C_HUMAN (1-127): 8.19e-54: 166: 85.04
+	Hs
		1038606 HDAC1_HUMAN (1-443): 0: 642: 90.07		H2B1A_HUMAN (1-127): 1.72e-52: 163: 100.00
+	Hs
		1038530 HDAC1_HUMAN (1-443): 0: 642: 90.07		H2B3B_HUMAN (1-127): 8.98e-51: 158: 85.83
+	Hs
		177352 HDAC3_HUMAN (10-431): 0: 574: 58.26		H2B1A_HUMAN (1-127): 1.72e-52: 163: 100.00
+	At
		1322590 HDA6_ARATH (1-467): 0: 578: 57.02		H2B10_ARATH (37-126): 2.54e-42: 138: 78.89
+	Sp
		140569 PHD1_SCHPO (7-411): 0: 519: 52.56		H2B1_SCHPO (5-126): 8.55e-46: 146: 69.67
+	Sc
		355947 HOS2_YEAST (11-430): 5.02e-174: 498: 47.18		H2B2_YEAST (4-126): 4.46e-41: 134: 69.36
+	Sc
		355966 HDA1_YEAST (9-330): 1.24e-121: 373: 27.56		H2B2_YEAST (4-126): 4.46e-41: 134: 69.36
+	Hs
		1307130 HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04		H2B1M_HUMAN (1-127): 6.74e-55: 169: 84.25
+	Hs
		241656 HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04		H2B1K_HUMAN (1-127): 8.56e-54: 166: 84.25
+	Hs
		707778 HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04		H2B1B_HUMAN (1-127): 6.87e-54: 166: 85.83
+	Hs
		886211 HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04		H2B1D_HUMAN (1-127): 1.37e-53: 166: 85.04
+	Hs
		1307148 HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04		H2B1L_HUMAN (1-127): 1.35e-52: 163: 85.83