HitPredict

Interactor 1: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Interactor 2: PF21A (Q96BD5)
PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80)
Gene: PHF21A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.746

Property	Details
Experiments	12032298, 34709266, 15325272, 12493763, 30737378, 35271311, 23752268, 21258344
Identification Methods	biochemical, proximity labelling technology, pull down, affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	association, physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000118 - histone deacetylase complex GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003682 - chromatin binding GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 488 Hs			1 680
+	Hs
		170436 HDAC2_HUMAN (1-488): 0: 707: 100.00		TIF1A_HUMAN (2-647): 1.34e-77: 270: 14.56
+	Hs
		1270501 HDAC2_HUMAN (1-488): 0: 707: 100.00		KDM5B_HUMAN (147-656): 5.55e-61: 224: 13.90
+	Hs
		782369 HDAC2_HUMAN (1-488): 0: 707: 100.00		KDM5C_HUMAN (169-655): 3.08e-60: 221: 15.75
+	Hs
		666546 HDAC2_HUMAN (1-488): 0: 707: 100.00		KDM5A_HUMAN (211-656): 1.39e-54: 204: 16.12
+	Mm
		56900 HDAC2_MOUSE (1-488): 0: 704: 99.39		CHD5_MOUSE (255-617): 1.37e-48: 186: 16.33
+	Hs
		1255037 HDAC2_HUMAN (1-488): 0: 707: 100.00		CHD5_HUMAN (255-617): 2.01e-43: 170: 16.79
+	Hs
		1059770 HDAC2_HUMAN (1-488): 0: 707: 100.00		CHD4_HUMAN (324-650): 1.2e-41: 165: 16.04
+	Hs
		1018617 HDAC2_HUMAN (1-488): 0: 707: 100.00		CHD3_HUMAN (298-617): 4.98e-41: 163: 15.21
+	Mm
		936393 HDAC2_MOUSE (1-488): 0: 704: 99.39		Q5DTP7_MOUSE (324-650): 3.03e-41: 164: 16.04
+	Dm
		1276545 HDAC1_DROME (5-472): 0: 653: 77.92		KDM5_DROME (79-655): 3.77e-57: 212: 11.99
+	Hs
		331858 HDAC2_HUMAN (1-488): 0: 707: 100.00		NSD2_HUMAN (77-547): 1.68e-36: 149: 11.77
+	Hs
		1270372 HDAC2_HUMAN (1-488): 0: 707: 100.00		PF21B_HUMAN (190-668): 6.44e-36: 144: 25.30
+	Dm
		1276536 HDAC1_DROME (5-472): 0: 653: 77.92		Q9VDK5_DROME (9-646): 8.16e-50: 190: 11.43
+	Dm
		68996 HDAC1_DROME (5-472): 0: 653: 77.92		A8WHL4_DROME (9-646): 2.35e-49: 188: 11.27
+	Dm
		332806 HDAC1_DROME (5-472): 0: 653: 77.92		CHDM_DROME (173-626): 2.63e-48: 185: 16.10
+	Mm
		56897 HDAC1_MOUSE (1-443): 0: 645: 90.29		CHD5_MOUSE (255-617): 1.37e-48: 186: 16.33
+	Mm
		140286 HDAC1_MOUSE (1-443): 0: 645: 90.29		CHD4_MOUSE (324-650): 3.17e-41: 164: 16.04
+	Hs
		217495 HDAC2_HUMAN (1-488): 0: 707: 100.00		AIRE_HUMAN (472-538): 1.24e-19: 94.9: 43.06
+	Hs
		1270388 HDAC2_HUMAN (1-488): 0: 707: 100.00		PHF12_HUMAN (462-541): 1.99e-13: 76: 31.71
+	Dm
		1276559 HDAC1_DROME (5-472): 0: 653: 77.92		Q9W410_DROME (350-607): 1.79e-13: 76: 16.86