HitPredict

Interactor 1: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Interactor 2: CHFR (Q96EP1)
E3 ubiquitin-protein ligase CHFR (EC 2.3.2.27) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196) (RING-type E3 ubiquitin transferase CHFR)
Gene: CHFR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	19182791
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 488 Hs			1 664
+	Hs
		1038622 HDAC1_HUMAN (1-443): 0: 642: 90.07		CHFR_HUMAN (1-664): 0: 904: 100.00
+	Hs
		718066 HDAC2_HUMAN (1-488): 0: 707: 100.00		BMI1_HUMAN (287-438): 5.06e-39: 148: 19.62
+	Hs
		1270421 HDAC2_HUMAN (1-488): 0: 707: 100.00		PCGF6_HUMAN (279-410): 5.03e-36: 140: 22.46
+	Hs
		1270400 HDAC2_HUMAN (1-488): 0: 707: 100.00		RING2_HUMAN (274-441): 1.28e-32: 130: 15.39
+	Mm
		936425 HDAC2_MOUSE (1-488): 0: 704: 99.39		RING2_MOUSE (274-441): 1.22e-32: 130: 15.39
+	Hs
		1038684 HDAC1_HUMAN (1-443): 0: 642: 90.07		PCGF6_HUMAN (279-410): 5.03e-36: 140: 22.46
+	Hs
		987966 HDAC1_HUMAN (1-443): 0: 642: 90.07		RING1_HUMAN (268-455): 9.62e-35: 138: 17.14
+	Hs
		1038656 HDAC1_HUMAN (1-443): 0: 642: 90.07		RING2_HUMAN (274-441): 1.28e-32: 130: 15.39