HitPredict

Interactor 1: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Interactor 2: PWP2A (Q96N64)
PWWP domain-containing protein 2A
Gene: PWWP2A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	24981860, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0006338 - chromatin remodeling GO:0042393 - histone binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 488 Hs			1 755
+	Hs
		1038633 HDAC1_HUMAN (1-443): 0: 642: 90.07		PWP2A_HUMAN (1-755): 5.64e-106: 343: 100.00
+	Hs
		1270494 HDAC2_HUMAN (1-488): 0: 707: 100.00		DNM3B_HUMAN (444-740): 8.42e-62: 224: 18.33
+	Rn
		100231 F7ENH8_RAT (1-488): 0: 706: 98.98		Q1LZ51_RAT (444-739): 4.73e-54: 202: 17.65
+	Hs
		1038858 HDAC1_HUMAN (1-443): 0: 642: 90.07		DNM3A_HUMAN (331-739): 1.19e-71: 253: 15.88
+	Hs
		1038468 HDAC1_HUMAN (1-443): 0: 642: 90.07		PWP2B_HUMAN (159-755): 9.75e-67: 233: 31.55
+	Hs
		1038774 HDAC1_HUMAN (1-443): 0: 642: 90.07		DNM3B_HUMAN (444-740): 8.42e-62: 224: 18.33
+	Hs
		203227 HDAC1_HUMAN (1-443): 0: 642: 90.07		SYNJ1_HUMAN (10-423): 1.01e-14: 80.7: 13.51
+	Hs
		1056969 HDAC8_HUMAN (33-372): 1.01e-137: 403: 43.40		MDC1_HUMAN (4-618): 1.16e-11: 70.7: 10.38