HitPredict

Interactor 1: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Interactor 2: PHF12 (Q96QT6)
PHD finger protein 12 (PHD factor 1) (Pf1)
Gene: PHF12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	26496610, 26841866, 24981860
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription GO:0070822 - Sin3-type complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 488 Hs			1 1004
+	Mm
		140269 HDAC1_MOUSE (1-443): 0: 645: 90.29		PHF12_MOUSE (1-1004): 0: 1349: 95.92
+	Dm
		1276559 HDAC1_DROME (5-472): 0: 653: 77.92		Q9W410_DROME (791-964): 1.53e-70: 254: 34.98
+	Hs
		170436 HDAC2_HUMAN (1-488): 0: 707: 100.00		TIF1A_HUMAN (10-272): 2.06e-32: 138: 18.08
+	Hs
		1017332 HDAC2_HUMAN (1-488): 0: 707: 100.00		BPTF_HUMAN (43-264): 2.26e-31: 135: 19.28
+	Hs
		1270364 HDAC2_HUMAN (1-488): 0: 707: 100.00		PF21A_HUMAN (1-241): 3.04e-30: 130: 16.21
+	Hs
		1270372 HDAC2_HUMAN (1-488): 0: 707: 100.00		PF21B_HUMAN (3-173): 8.73e-30: 127: 22.22
+	Mm
		56900 HDAC2_MOUSE (1-488): 0: 704: 99.39		CHD5_MOUSE (5-166): 1.64e-22: 106: 17.54
+	Hs
		1255037 HDAC2_HUMAN (1-488): 0: 707: 100.00		CHD5_HUMAN (15-166): 1.47e-20: 100: 16.77
+	Hs
		1059770 HDAC2_HUMAN (1-488): 0: 707: 100.00		CHD4_HUMAN (52-166): 3.04e-20: 99.6: 19.23
+	Hs
		1018617 HDAC2_HUMAN (1-488): 0: 707: 100.00		CHD3_HUMAN (11-166): 1.58e-19: 97.3: 16.96
+	Mm
		936393 HDAC2_MOUSE (1-488): 0: 704: 99.39		Q5DTP7_MOUSE (52-166): 3.27e-20: 99.2: 16.15
+	Hs
		217495 HDAC2_HUMAN (1-488): 0: 707: 100.00		AIRE_HUMAN (54-114): 4.23e-16: 84.8: 44.26
+	Hs
		170356 HDAC1_HUMAN (1-443): 0: 642: 90.07		TIF1A_HUMAN (10-272): 2.06e-32: 138: 18.08
+	Dm
		332806 HDAC1_DROME (5-472): 0: 653: 77.92		CHDM_DROME (50-278): 8.02e-29: 127: 16.47
+	Hs
		1017292 HDAC1_HUMAN (1-443): 0: 642: 90.07		BPTF_HUMAN (43-264): 2.26e-31: 135: 19.28
+	Mm
		56897 HDAC1_MOUSE (1-443): 0: 645: 90.29		CHD5_MOUSE (5-166): 1.64e-22: 106: 17.54
+	Mm
		140286 HDAC1_MOUSE (1-443): 0: 645: 90.29		CHD4_MOUSE (52-166): 3.12e-20: 99.6: 16.15
+	Mm
		140293 HDAC1_MOUSE (1-443): 0: 645: 90.29		KDM5B_MOUSE (23-112): 8.34e-20: 97.9: 29.03
+	Hs
		1018465 HDAC1_HUMAN (1-443): 0: 642: 90.07		CHD3_HUMAN (11-166): 1.58e-19: 97.3: 16.96
+	Hs
		217477 HDAC1_HUMAN (1-443): 0: 642: 90.07		AIRE_HUMAN (54-114): 4.23e-16: 84.8: 44.26