HitPredict

Interactor 1: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Interactor 2: CIC (Q96RK0)
Protein capicua homolog
Gene: CIC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29844126
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 488 Hs			1 2517
+	Hs
		1038645 HDAC1_HUMAN (1-443): 0: 642: 90.07		CIC_HUMAN (1-2517): 0: 961: 100.00
+	Hs
		818314 HDAC2_HUMAN (1-488): 0: 707: 100.00		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Mm
		936399 HDAC2_MOUSE (1-488): 0: 704: 99.39		Q60I23_MOUSE (1102-1308): 2.84e-56: 201: 27.40
+	Mm
		818688 HDAC2_MOUSE (1-488): 0: 704: 99.39		SOX2_MOUSE (1102-1308): 3.32e-55: 198: 26.44
+	Hs
		727903 HDAC2_HUMAN (1-488): 0: 707: 100.00		SOX6_HUMAN (887-1289): 5.1e-35: 148: 16.28
+	Mm
		140273 HDAC1_MOUSE (1-443): 0: 645: 90.29		Q60I23_MOUSE (1102-1308): 2.84e-56: 201: 27.40
+	Hs
		818023 HDAC1_HUMAN (1-443): 0: 642: 90.07		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Mm
		140241 HDAC1_MOUSE (1-443): 0: 645: 90.29		SOX2_MOUSE (1102-1308): 3.32e-55: 198: 26.44
+	Xl
		1193361 Q7ZYT5_XENLA (1-486): 0: 678: 87.04		Q90ZB8_XENLA (921-1200): 1.01e-34: 140: 22.50
+	Hs
		727863 HDAC1_HUMAN (1-443): 0: 642: 90.07		SOX6_HUMAN (887-1289): 5.1e-35: 148: 16.28
+	Hs
		1038578 HDAC1_HUMAN (1-443): 0: 642: 90.07		BBX_HUMAN (1078-1189): 1.69e-34: 147: 48.21
+	Hs
		1270546 HDAC2_HUMAN (1-488): 0: 707: 100.00		NCOR2_HUMAN (290-1816): 8.11e-14: 80.2: 8.06
+	Hs
		1270545 HDAC2_HUMAN (1-488): 0: 707: 100.00		PRC2C_HUMAN (310-2236): 1.98e-13: 79.1: 9.20
+	Hs
		177229 HDAC3_HUMAN (10-431): 0: 574: 58.26		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Hs
		1038795 HDAC1_HUMAN (1-443): 0: 642: 90.07		LEF1_HUMAN (929-1200): 1.93e-32: 134: 21.82
+	Hs
		1270531 HDAC2_HUMAN (1-488): 0: 707: 100.00		SRRM2_HUMAN (291-1369): 4.76e-10: 67.9: 8.34
+	Hs
		1038652 HDAC1_HUMAN (1-443): 0: 642: 90.07		MINT_HUMAN (730-2515): 3e-28: 127: 9.45
+	Ce
		184841 HDA1_CAEEL (7-456): 0: 595: 64.02		POP1_CAEEL (959-1182): 1.17e-34: 141: 22.17
+	Hs
		1038852 HDAC1_HUMAN (1-443): 0: 642: 90.07		NCOR2_HUMAN (290-1816): 8.11e-14: 80.2: 8.06
+	Hs
		177214 HDAC3_HUMAN (10-431): 0: 574: 58.26		SOX6_HUMAN (887-1289): 5.1e-35: 148: 16.28