HitPredict

Interactor 1: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Interactor 2: GFI1 (Q99684)
Zinc finger protein Gfi-1 (Growth factor independent protein 1) (Zinc finger protein 163)
Gene: GFI1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	31289136, 17707228
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0010977 - negative regulation of neuron projection development GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 488 Hs			1 422
+	Hs
		1038663 HDAC1_HUMAN (1-443): 0: 642: 90.07		GFI1_HUMAN (1-422): 6.63e-149: 430: 100.00
+	Hs
		161857 HDAC2_HUMAN (1-488): 0: 707: 100.00		ZN263_HUMAN (9-422): 3.13e-116: 356: 24.11
+	Hs
		1138065 HDAC2_HUMAN (1-488): 0: 707: 100.00		GFI1B_HUMAN (251-422): 2.59e-101: 306: 87.79
+	Mm
		250551 HDAC2_MOUSE (1-488): 0: 704: 99.39		GFI1B_MOUSE (251-422): 7.65e-101: 305: 87.79
+	Mm
		140207 HDAC1_MOUSE (1-443): 0: 645: 90.29		GFI1B_MOUSE (251-422): 7.65e-101: 305: 87.79
+	Hs
		1158943 HDAC2_HUMAN (1-488): 0: 707: 100.00		ZFP1_HUMAN (186-339): 1.18e-63: 211: 21.91
+	Hs
		1193248 HDAC8_HUMAN (33-372): 1.01e-137: 403: 43.40		ZSCA2_HUMAN (4-422): 2.08e-139: 413: 22.38
+	Hs
		599074 HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04		ZNF10_HUMAN (109-396): 3.37e-73: 241: 22.11