HitPredict

Interactor 1: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Interactor 2: EPAS1 (Q99814)
Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)
Gene: EPAS1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	33591636
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 488 Hs			1 870
+	Hs
		1038669 HDAC1_HUMAN (1-443): 0: 642: 90.07		EPAS1_HUMAN (1-870): 0: 863: 100.00
+	Hs
		1085622 HDAC2_HUMAN (1-488): 0: 707: 100.00		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Hs
		1038422 HDAC1_HUMAN (1-443): 0: 642: 90.07		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Hs
		177311 HDAC3_HUMAN (10-431): 0: 574: 58.26		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Hs
		649101 HDAC1_HUMAN (1-443): 0: 642: 90.07		ARNT_HUMAN (2-644): 5.31e-129: 407: 19.24
+	Hs
		177366 HDAC3_HUMAN (10-431): 0: 574: 58.26		NPAS1_HUMAN (1-522): 8.79e-103: 332: 23.12
+	Hs
		1085703 HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Hs
		1085616 HDAC7_HUMAN (29-280): 1.96e-23: 106: 26.37		HIF1A_HUMAN (3-868): 0: 553: 42.32