HitPredict

Interactor 1: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Interactor 2: SIR7 (Q9NRC8)
NAD-dependent protein deacetylase sirtuin-7 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-7) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7)
Gene: SIRT7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22586326
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0005737 - cytoplasm
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 488 Hs			1 400
+	Hs
		1236414 HDAC2_HUMAN (1-488): 0: 707: 100.00		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87
+	Hs
		1270371 HDAC2_HUMAN (1-488): 0: 707: 100.00		SIR1_HUMAN (78-380): 5.06e-78: 257: 19.94
+	Hs
		1038539 HDAC1_HUMAN (1-443): 0: 642: 90.07		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87
+	Mm
		140308 HDAC1_MOUSE (1-443): 0: 645: 90.29		SIR1_MOUSE (78-380): 5.54e-78: 256: 19.94
+	Hs
		1038619 HDAC1_HUMAN (1-443): 0: 642: 90.07		SIR1_HUMAN (78-380): 5.06e-78: 257: 19.94
+	Hs
		177336 HDAC3_HUMAN (10-431): 0: 574: 58.26		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87
+	Sc
		859057 HOS2_YEAST (11-430): 5.02e-174: 498: 47.18		HST1_YEAST (31-366): 1.51e-88: 278: 19.32
+	Hs
		1220779 HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04		SIR2_HUMAN (75-380): 1.48e-97: 298: 21.26
+	Hs
		1354188 HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04		SIR4_HUMAN (78-322): 3.55e-81: 253: 27.88