HitPredict

Interactor 1: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Interactor 2: RCOR3 (Q9P2K3)
REST corepressor 3
Gene: RCOR3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.925

Property	Details
Experiments	24981860, 35271311, 21258344, 23752268, 26949739
Identification Methods	affinity chromatography technology, cross-linking study, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ELM2~Hist_deacetyl, Hist_deacetyl~Myb_DNA-binding
Common GO terms	GO:0000118 - histone deacetylase complex GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 488 Hs			1 495
+	Hs
		1270515 HDAC2_HUMAN (1-488): 0: 707: 100.00		RCOR1_HUMAN (1-384): 4.93e-99: 308: 62.69
+	Mm
		936418 HDAC2_MOUSE (1-488): 0: 704: 99.39		RCOR1_MOUSE (1-385): 5.12e-99: 308: 63.57
+	Hs
		296092 HDAC2_HUMAN (1-488): 0: 707: 100.00		MTA2_HUMAN (1-478): 7.19e-92: 295: 15.71
+	Mm
		936428 HDAC2_MOUSE (1-488): 0: 704: 99.39		MTA2_MOUSE (1-478): 1.74e-92: 297: 15.53
+	Mm
		936416 HDAC2_MOUSE (1-488): 0: 704: 99.39		RCOR2_MOUSE (1-494): 1.38e-93: 295: 55.44
+	Hs
		1223936 HDAC2_HUMAN (1-488): 0: 707: 100.00		RCOR2_HUMAN (1-494): 4.22e-92: 291: 55.44
+	Hs
		1270415 HDAC2_HUMAN (1-488): 0: 707: 100.00		MTA3_HUMAN (1-418): 1.98e-89: 287: 15.86
+	Hs
		1031919 HDAC2_HUMAN (1-488): 0: 707: 100.00		MTA1_HUMAN (1-433): 2.17e-85: 279: 15.62
+	Mm
		936419 HDAC2_MOUSE (1-488): 0: 704: 99.39		MTA1_MOUSE (1-433): 5.29e-85: 278: 15.82
+	Mm
		140301 HDAC1_MOUSE (1-443): 0: 645: 90.29		RCOR1_MOUSE (1-385): 5.12e-99: 308: 63.57
+	Mm
		140302 HDAC1_MOUSE (1-443): 0: 645: 90.29		MTA1_MOUSE (1-433): 5.29e-85: 278: 15.82
+	Dm
		1276548 HDAC1_DROME (5-472): 0: 653: 77.92		Q9VNF6_DROME (1-493): 6.61e-73: 249: 15.23
+	Dm
		81423 HDAC1_DROME (5-472): 0: 653: 77.92		B7Z0T5_DROME (1-493): 5.73e-73: 248: 15.23
+	Hs
		1270490 HDAC2_HUMAN (1-488): 0: 707: 100.00		RERE_HUMAN (1-495): 8.77e-50: 185: 16.40
+	Hs
		1270546 HDAC2_HUMAN (1-488): 0: 707: 100.00		NCOR2_HUMAN (35-478): 1.59e-48: 182: 18.57
+	Hs
		1189328 HDAC2_HUMAN (1-488): 0: 707: 100.00		MIER3_HUMAN (1-238): 1.22e-49: 180: 20.54
+	Hs
		1231960 HDAC2_HUMAN (1-488): 0: 707: 100.00		MIER2_HUMAN (1-306): 1.16e-43: 163: 18.98
+	Hs
		1229946 HDAC2_HUMAN (1-488): 0: 707: 100.00		MIER1_HUMAN (1-307): 1.08e-41: 157: 18.68
+	Mm
		140291 HDAC1_MOUSE (1-443): 0: 645: 90.29		RERE_MOUSE (1-495): 3.41e-51: 189: 17.00
+	Dm
		1123842 HDAC1_DROME (5-472): 0: 653: 77.92		RCOR_DROME (1-484): 4.5e-49: 179: 27.16