HitPredict

Interactor 1: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Interactor 2: IKZF3 (Q9UKT9)
Zinc finger protein Aiolos (Ikaros family zinc finger protein 3)
Gene: IKZF3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	30760870, 12015313, 35583604
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0042826 - histone deacetylase binding GO:1990841 - promoter-specific chromatin binding
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 488 Hs			1 509
+	Hs
		1270517 HDAC2_HUMAN (1-488): 0: 707: 100.00		IKZF2_HUMAN (4-504): 3.73e-144: 426: 46.98
+	Hs
		1033690 HDAC2_HUMAN (1-488): 0: 707: 100.00		IKZF1_HUMAN (31-505): 1.69e-140: 416: 55.51
+	Hs
		1270436 HDAC2_HUMAN (1-488): 0: 707: 100.00		IKZF4_HUMAN (110-505): 5.69e-135: 404: 50.35
+	Hs
		1038804 HDAC1_HUMAN (1-443): 0: 642: 90.07		IKZF2_HUMAN (4-504): 3.73e-144: 426: 46.98
+	Hs
		1033633 HDAC1_HUMAN (1-443): 0: 642: 90.07		IKZF1_HUMAN (31-505): 1.69e-140: 416: 55.51
+	Hs
		1038805 HDAC1_HUMAN (1-443): 0: 642: 90.07		IKZF3_HUMAN (1-509): 2.04e-134: 400: 100.00
+	Hs
		177285 HDAC3_HUMAN (10-431): 0: 574: 58.26		IKZF1_HUMAN (31-505): 1.69e-140: 416: 55.51
+	Mm
		936415 HDAC2_MOUSE (1-488): 0: 704: 99.39		Q8C5P6_MOUSE (112-230): 1.84e-63: 209: 83.19
+	Mm
		140300 HDAC1_MOUSE (1-443): 0: 645: 90.29		Q8C5P6_MOUSE (112-230): 1.84e-63: 209: 83.19
+	Hs
		1193248 HDAC8_HUMAN (33-372): 1.01e-137: 403: 43.40		ZSCA2_HUMAN (2-406): 4.23e-118: 361: 18.45
+	Hs
		1038377 HDAC1_HUMAN (1-443): 0: 642: 90.07		ZN273_HUMAN (135-222): 2.41e-11: 68.2: 37.50
+	Hs
		1033686 HDAC7_HUMAN (29-280): 1.96e-23: 106: 26.37		IKZF1_HUMAN (31-505): 1.69e-140: 416: 55.51
+	Hs
		1260190 HDAC7_HUMAN (29-280): 1.96e-23: 106: 26.37		IKZF4_HUMAN (110-505): 5.69e-135: 404: 50.35
+	Hs
		1260200 HDAC7_HUMAN (29-280): 1.96e-23: 106: 26.37		IKZF3_HUMAN (1-509): 2.04e-134: 400: 100.00