HitPredict

Interactor 1: STAM1 (Q92783)
Signal transducing adapter molecule 1 (STAM-1)
Gene: STAM

Interactor 2: PTN23 (Q9H3S7)
Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14)
Gene: PTPN23

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	26456826, 34761192
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043231 - intracellular membrane-bounded organelle GO:0043328 - protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 540 Hs			1 1636
+	Hs
		277131 STAM2_HUMAN (1-533): 8.53e-122: 369: 54.65		PTN23_HUMAN (1-1636): 0: 1052: 100.00
+	Hs
		1173028 TM1L2_HUMAN (6-435): 1.81e-70: 236: 18.45		PTN23_HUMAN (1-1636): 0: 1052: 100.00
+	Hs
		241197 TOM1_HUMAN (6-454): 3.66e-69: 232: 16.81		PTN23_HUMAN (1-1636): 0: 1052: 100.00
+	Hs
		160187 HGS_HUMAN (84-540): 8.62e-15: 79.4: 13.50		PTN23_HUMAN (1-1636): 0: 1052: 100.00
+	Hs
		275227 GRAP2_HUMAN (213-264): 2.75e-14: 75.9: 57.69		PTN23_HUMAN (1-1636): 0: 1052: 100.00
+	Mm
		292687 GRAP2_MOUSE (213-264): 1.05e-13: 73.9: 55.77		PTN23_MOUSE (1-1636): 0: 996: 87.33
+	Hs
		1260371 STAM1_HUMAN (1-518): 1.32e-126: 382: 100.00		PDC6I_HUMAN (9-871): 7.58e-165: 523: 22.24
+	Hs
		277001 STAM2_HUMAN (1-533): 8.53e-122: 369: 54.65		PTN1_HUMAN (1206-1566): 2.6e-121: 390: 26.39
+	Mm
		1141174 GRB2_MOUSE (215-265): 2.65e-13: 71.2: 54.90		PDC6I_MOUSE (9-871): 1.47e-162: 517: 22.77
+	Hs
		573654 GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90		PTN1_HUMAN (1206-1566): 2.6e-121: 390: 26.39
+	Hs
		665853 GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90		PTN6_HUMAN (1159-1472): 7.88e-118: 386: 23.96
+	Dm
		1280452 HRS_DROME (7-145): 4.23e-40: 156: 31.43		Q9VUH6_DROME (254-1486): 4.08e-59: 227: 13.48
+	Mm
		574006 GRB2_MOUSE (215-265): 2.65e-13: 71.2: 54.90		PTPRA_MOUSE (1205-1455): 8.37e-89: 311: 30.59
+	Hs
		577009 GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90		PTPRA_HUMAN (1205-1455): 7.92e-89: 310: 30.59
+	Hs
		617047 GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90		PTPRE_HUMAN (1208-1453): 1.74e-80: 283: 32.55
+	Hs
		146925 GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90		PTPRT_HUMAN (1177-1455): 1.05e-54: 212: 22.73
+	Hs
		663972 GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90		PTN4_HUMAN (1220-1455): 2.79e-30: 132: 33.33
+	Mm
		719305 GRB2_MOUSE (215-265): 2.65e-13: 71.2: 54.90		PTN11_MOUSE (1195-1459): 4.76e-30: 129: 30.63
+	Rn
		783504 GRB2_RAT (215-265): 2.32e-13: 71.2: 54.90		PTN11_RAT (1195-1459): 6.28e-30: 129: 31.47
+	Hs
		924502 GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90		PTN11_HUMAN (1195-1459): 5.34e-30: 129: 30.63