HitPredict

Interactor 1: CBP (Q92793)
CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
Gene: CREBBP

Interactor 2: NPAS2 (Q99743)
Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Basic-helix-loop-helix-PAS protein MOP4) (Class E basic helix-loop-helix protein 9) (bHLHe9) (Member of PAS protein 4) (PAS domain-containing protein 4)
Gene: NPAS2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	14645221
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2442 Hs			1 824
+	Hs
		181549 CBP_HUMAN (1-2442): 0: 1104: 100.00		CLOCK_HUMAN (1-782): 2.98e-127: 403: 48.81
+	Hs
		1085623 CBP_HUMAN (1-2442): 0: 1104: 100.00		HIF1A_HUMAN (2-798): 6.81e-126: 399: 16.22
+	Mm
		101411 F8VPR5_MOUSE (1-2442): 0: 1077: 95.67		CLOCK_MOUSE (1-824): 6.7e-129: 408: 47.85
+	Rn
		193481 CBP_RAT (1-2442): 0: 1080: 95.62		HIF1A_RAT (2-798): 5.38e-128: 404: 15.94
+	Hs
		126156 CBP_HUMAN (1-2442): 0: 1104: 100.00		BMAL1_HUMAN (2-480): 6.13e-113: 359: 23.17
+	Hs
		1270775 CBP_HUMAN (1-2442): 0: 1104: 100.00		EPAS1_HUMAN (2-727): 1.35e-102: 338: 16.15
+	Hs
		1075384 CBP_HUMAN (1-2442): 0: 1104: 100.00		NCOA2_HUMAN (2-729): 3.56e-93: 321: 15.60
+	Mm
		799605 CBP_MOUSE (1-2442): 0: 1060: 95.22		BMAL1_MOUSE (2-480): 2.77e-113: 360: 23.17
+	Mm
		799600 CBP_MOUSE (1-2442): 0: 1060: 95.22		BMAL2_MOUSE (11-512): 7.84e-97: 315: 21.20
+	Hs
		999018 EP300_HUMAN (1-2426): 0: 874: 55.06		NPAS2_HUMAN (1-824): 3.41e-135: 423: 100.00
+	Hs
		181518 EP300_HUMAN (1-2426): 0: 874: 55.06		CLOCK_HUMAN (1-782): 2.98e-127: 403: 48.81
+	Hs
		998777 EP300_HUMAN (1-2426): 0: 874: 55.06		HIF1A_HUMAN (2-798): 6.81e-126: 399: 16.22
+	Hs
		126124 EP300_HUMAN (1-2426): 0: 874: 55.06		BMAL1_HUMAN (2-480): 6.13e-113: 359: 23.17
+	Hs
		999019 EP300_HUMAN (1-2426): 0: 874: 55.06		EPAS1_HUMAN (2-727): 1.35e-102: 338: 16.15
+	Hs
		649093 EP300_HUMAN (1-2426): 0: 874: 55.06		ARNT_HUMAN (5-667): 1.9e-101: 333: 20.31
+	Hs
		998745 EP300_HUMAN (1-2426): 0: 874: 55.06		NCOA2_HUMAN (2-729): 3.56e-93: 321: 15.60
+	Hs
		728907 EP300_HUMAN (1-2426): 0: 874: 55.06		AHR_HUMAN (14-803): 3.49e-89: 302: 14.44
+	Hs
		1078530 CBP_HUMAN (1-2442): 0: 1104: 100.00		NCOA1_HUMAN (15-186): 1.58e-09: 63.9: 29.73
+	Hs
		998754 EP300_HUMAN (1-2426): 0: 874: 55.06		NCOA1_HUMAN (15-186): 1.58e-09: 63.9: 29.73
+	Mm
		70907 EP300_MOUSE (1-2426): 0: 867: 53.61		NCOA1_MOUSE (15-186): 4.85e-10: 65.5: 30.27