HitPredict

Interactor 1: CBP (Q92793)
CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
Gene: CREBBP

Interactor 2: NCOA3 (Q9Y6Q9)
Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)
Gene: NCOA3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.977

The method score is based on:

Property Details
Experiments 8616895, 9192892, 15383283, 21632823, 11076796, 11971985, 33589584, 17043108, 9346901, 21914189, 16227615, 26267537
Identification Methods pull down, affinity chromatography technology, two hybrid, biochemical, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Creb_binding~Nuc_rec_co-act
Common GO terms GO:0000785 - chromatin
GO:0003713 - transcription coactivator activity
GO:0004402 - histone acetyltransferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 2442
Hs

1 1424
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Rn
+ Mm
+ Hs
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024