HitPredict

Interactor 1: SYMPK (Q92797)
Symplekin
Gene: SYMPK

Interactor 2: CPSF3 (Q9UKF6)
Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73)
Gene: CPSF3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	26496610, 36652389, 24981860, 18688255, 35177536
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation, molecular sieving, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1274 Hs			1 684
+	Hs
		1271078 SYMPK_HUMAN (1-1274): 0: 1736: 100.00		CPSF2_HUMAN (12-640): 8.58e-180: 532: 19.17
+	Dm
		1229164 SYMPK_DROME (7-1132): 0: 1182: 35.75		CPSF3_DROME (4-680): 0: 718: 67.31
+	Dm
		1229160 SYMPK_DROME (7-1132): 0: 1182: 35.75		CPSF2_DROME (12-575): 4.9e-138: 424: 18.37
+	At
		1338483 Q9M033_ARATH (32-1100): 0: 844: 24.14		CPSF2_ARATH (9-564): 4.62e-115: 364: 18.37
+	Sp
		142961 PTA1_SCHPO (49-706): 0: 557: 17.36		YSH1_SCHPO (5-682): 0: 649: 46.82
+	Sc
		964626 PTA1_YEAST (49-739): 1.6e-93: 321: 15.01		YSH1_YEAST (4-683): 0: 589: 38.83
+	Sc
		964632 PTA1_YEAST (49-739): 1.6e-93: 321: 15.01		CFT2_YEAST (18-483): 4.75e-77: 265: 15.96
+	Sc
		964628 PTA1_YEAST (49-739): 1.6e-93: 321: 15.01		SYC1_YEAST (512-683): 2.04e-31: 123: 15.93