HitPredict

Interactor 1: EZH1 (Q92800)
Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1)
Gene: EZH1

Interactor 2: LCOR (Q96JN0)
Ligand-dependent corepressor (LCoR) (Mblk1-related protein 2)
Gene: LCOR

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	27705803, 24981860, 33961781
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 747 Hs			1 433
+	Mm
		1142279 EZH2_MOUSE (8-746): 0: 724: 63.04		LCOR_MOUSE (1-433): 0: 605: 97.92
+	Hs
		1080239 EZH2_HUMAN (8-746): 0: 719: 62.78		LCOR_HUMAN (1-433): 0: 607: 100.00
+	Mm
		1169599 EHMT2_MOUSE (419-733): 2.05e-74: 264: 23.38		LCOR_MOUSE (1-433): 0: 605: 97.92
+	Hs
		1295459 EHMT2_HUMAN (419-733): 7.51e-74: 262: 23.10		LCOR_HUMAN (1-433): 0: 607: 100.00
+	Hs
		57021 A2ABF9_HUMAN (419-733): 9.25e-74: 262: 23.10		LCOR_HUMAN (1-433): 0: 607: 100.00