HitPredict

Interactor 1: EZH1 (Q92800)
Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1)
Gene: EZH1

Interactor 2: PWP2A (Q96N64)
PWWP domain-containing protein 2A
Gene: PWWP2A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0006338 - chromatin remodeling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 747 Hs			1 755
+	Hs
		1080249 EZH2_HUMAN (8-746): 0: 719: 62.78		PWP2A_HUMAN (1-755): 5.64e-106: 343: 100.00
+	Mm
		291731 EZH2_MOUSE (8-746): 0: 724: 63.04		DNM3A_MOUSE (346-739): 9.35e-74: 259: 16.83
+	Hs
		1080532 EZH2_HUMAN (8-746): 0: 719: 62.78		DNM3A_HUMAN (331-739): 1.19e-71: 253: 15.88
+	Hs
		1080430 EZH2_HUMAN (8-746): 0: 719: 62.78		DNM3B_HUMAN (444-740): 8.42e-62: 224: 18.33
+	Mm
		291747 EZH2_MOUSE (8-746): 0: 724: 63.04		DNM3B_MOUSE (444-740): 5.66e-48: 184: 15.26
+	Hs
		1080520 EZH2_HUMAN (8-746): 0: 719: 62.78		CRBG1_HUMAN (7-679): 5.54e-28: 123: 12.91
+	Hs
		554310 EZH2_HUMAN (8-746): 0: 719: 62.78		MUC1_HUMAN (76-652): 1.04e-15: 83.8: 10.88
+	Mm
		291740 EHMT2_MOUSE (419-733): 2.05e-74: 264: 23.38		DNM3A_MOUSE (346-739): 9.35e-74: 259: 16.83
+	Hs
		203822 SUV91_HUMAN (422-732): 2.51e-81: 267: 22.98		DNM3A_HUMAN (331-739): 1.19e-71: 253: 15.88
+	Hs
		1296452 EHMT2_HUMAN (419-733): 7.51e-74: 262: 23.10		DNM3A_HUMAN (331-739): 1.19e-71: 253: 15.88
+	Mm
		291729 EHMT1_MOUSE (416-734): 1.63e-71: 256: 22.65		DNM3A_MOUSE (346-739): 9.35e-74: 259: 16.83
+	Hs
		1334149 EHMT1_HUMAN (416-733): 2.04e-73: 261: 21.88		DNM3A_HUMAN (331-739): 1.19e-71: 253: 15.88
+	Hs
		203801 SUV91_HUMAN (422-732): 2.51e-81: 267: 22.98		DNM3B_HUMAN (444-740): 8.42e-62: 224: 18.33
+	Hs
		1296428 EHMT2_HUMAN (419-733): 7.51e-74: 262: 23.10		DNM3B_HUMAN (444-740): 8.42e-62: 224: 18.33
+	Mm
		291753 EHMT2_MOUSE (419-733): 2.05e-74: 264: 23.38		DNM3B_MOUSE (444-740): 5.66e-48: 184: 15.26
+	Hs
		1056971 SETD2_HUMAN (181-733): 3.89e-76: 271: 14.90		MDC1_HUMAN (4-618): 1.16e-11: 70.7: 10.38
+	Hs
		331812 NSD2_HUMAN (471-730): 3.64e-61: 225: 24.09		MDC1_HUMAN (4-618): 1.16e-11: 70.7: 10.38
+	Hs
		1056940 NSD1_HUMAN (472-730): 1.84e-55: 208: 23.55		MDC1_HUMAN (4-618): 1.16e-11: 70.7: 10.38
+	Dm
		54311 SET1_DROME (612-733): 3.98e-19: 94.7: 39.52		A1Z9J3_DROME (7-452): 1.98e-15: 83.4: 13.22
+	Hs
		975294 KMT2A_HUMAN (620-734): 4.36e-19: 95.1: 42.24		TITIN_HUMAN (32-662): 9.5e-09: 61.5: 10.97