HitPredict

Interactor 1: KAT2A (Q92830)
Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (hGCN5) (Histone glutaryltransferase KAT2A) (EC 2.3.1.-) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine acetyltransferase 2A) (STAF97)
Gene: KAT2A

Interactor 2: DTL (Q9NZJ0)
Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein)
Gene: DTL

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	21987584
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Acetyltransf_1~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005813 - centrosome GO:0051726 - regulation of cell cycle
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 837 Hs			1 730
+	Mm
		903679 KAT2A_MOUSE (1-837): 0: 1161: 97.14		WDR5_MOUSE (11-243): 2.2e-54: 192: 13.95
+	Hs
		903408 KAT2A_HUMAN (75-837): 0: 1159: 100.00		WDR5_HUMAN (11-243): 2.2e-54: 192: 13.95
+	Hs
		903409 KAT2B_HUMAN (84-837): 0: 1095: 74.31		WDR5_HUMAN (11-243): 2.2e-54: 192: 13.95
+	Dm
		1358857 Q9VTZ1_DROME (63-837): 0: 965: 47.45		WDS_DROME (8-172): 1e-29: 123: 15.64
+	Sc
		863629 GCN5_YEAST (414-834): 9.11e-169: 497: 39.07		COPA_YEAST (14-377): 7.56e-32: 135: 11.55
+	Hs
		631541 BRD2_HUMAN (691-837): 3.87e-36: 148: 27.63		FBXW7_HUMAN (175-521): 4.51e-54: 200: 12.16
+	Hs
		903172 EP300_HUMAN (652-832): 2.03e-37: 154: 19.02		WDR5_HUMAN (11-243): 2.2e-54: 192: 13.95
+	Hs
		170444 TIF1A_HUMAN (626-832): 1.23e-44: 176: 22.86		SNR40_HUMAN (258-581): 7.14e-39: 149: 13.90
+	Hs
		244210 BRD4_HUMAN (657-833): 1.8e-30: 131: 21.43		WDR5_HUMAN (11-243): 2.2e-54: 192: 13.95
+	Hs
		1288368 BAZ2B_HUMAN (627-829): 5.79e-41: 165: 19.90		SNR40_HUMAN (258-581): 7.14e-39: 149: 13.90
+	Hs
		1288369 BAZ2A_HUMAN (647-837): 1.05e-36: 151: 22.51		SNR40_HUMAN (258-581): 7.14e-39: 149: 13.90
+	Hs
		244767 BRD4_HUMAN (657-833): 1.8e-30: 131: 21.43		SNR40_HUMAN (258-581): 7.14e-39: 149: 13.90
+	Hs
		600117 TAF1_HUMAN (733-831): 8.58e-09: 61.6: 30.30		WDR5_HUMAN (11-243): 2.2e-54: 192: 13.95
+	Hs
		236212 EP300_HUMAN (652-832): 2.03e-37: 154: 19.02		PRP17_HUMAN (16-169): 9.6e-20: 95.8: 16.97
+	Hs
		1346964 BAZ2B_HUMAN (627-829): 5.79e-41: 165: 19.90		NLE1_HUMAN (343-590): 4e-15: 80.5: 10.97
+	Hs
		1346965 BAZ2A_HUMAN (647-837): 1.05e-36: 151: 22.51		NLE1_HUMAN (343-590): 4e-15: 80.5: 10.97
+	Hs
		243688 BRD4_HUMAN (657-833): 1.8e-30: 131: 21.43		TBL1X_HUMAN (9-129): 3.35e-16: 84.4: 12.14
+	Hs
		244909 BRD4_HUMAN (657-833): 1.8e-30: 131: 21.43		WDR12_HUMAN (227-403): 1.54e-14: 78.4: 20.00
+	Hs
		244901 BRD4_HUMAN (657-833): 1.8e-30: 131: 21.43		TBL1R_HUMAN (345-620): 1.5e-12: 72.8: 11.68