HitPredict

Interactor 1: SHIP1 (Q92835)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN)
Gene: INPP5D

Interactor 2: LY9 (Q9HBG7)
T-lymphocyte surface antigen Ly-9 (Cell surface molecule Ly-9) (Lymphocyte antigen 9) (SLAM family member 3) (SLAMF3) (Signaling lymphocytic activation molecule 3) (CD antigen CD229)
Gene: LY9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	26221972
Identification Methods	surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1189 Hs			1 655
+	Hs
		1271567 SHIP1_HUMAN (1-1189): 0: 883: 100.00		SLAF7_HUMAN (243-538): 2.12e-60: 207: 27.12
+	Hs
		1030743 SHIP1_HUMAN (1-1189): 0: 883: 100.00		SLAF1_HUMAN (25-263): 4.62e-43: 160: 24.41
+	Mm
		1322348 SHIP1_MOUSE (1-1189): 0: 858: 87.11		SLAF1_MOUSE (28-274): 2.46e-46: 169: 23.31
+	Hs
		1271565 SHIP1_HUMAN (1-1189): 0: 883: 100.00		CD244_HUMAN (44-379): 3.34e-14: 76.5: 17.31
+	Hs
		590610 SHIP1_HUMAN (1-1189): 0: 883: 100.00		CD22_HUMAN (253-637): 5.7e-13: 74.3: 12.07
+	Mm
		722908 SHIP1_MOUSE (1-1189): 0: 858: 87.11		CD22_MOUSE (61-431): 4.56e-15: 81.1: 17.40
+	Hs
		176495 SHIP2_HUMAN (3-1169): 0: 697: 39.77		CD244_HUMAN (44-379): 3.34e-14: 76.5: 17.31
+	Hs
		243157 SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26		LY9_HUMAN (1-655): 1.6e-147: 444: 100.00
+	Hs
		243158 SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26		SLAF7_HUMAN (243-538): 2.12e-60: 207: 27.12
+	Hs
		243161 SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26		SLAF5_HUMAN (33-244): 1.73e-60: 207: 38.01
+	Hs
		243153 SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26		SLAF6_HUMAN (32-254): 9.4e-51: 180: 32.47
+	Mm
		292400 SH21A_MOUSE (7-116): 3.21e-22: 95.1: 44.55		SLAF1_MOUSE (28-274): 2.46e-46: 169: 23.31
+	Hs
		243137 SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26		SLAF1_HUMAN (25-263): 4.62e-43: 160: 24.41
+	Hs
		243155 SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26		CD244_HUMAN (44-379): 3.34e-14: 76.5: 17.31
+	Hs
		243129 SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26		CD22_HUMAN (253-637): 5.7e-13: 74.3: 12.07