Interactor 1: B2CL2 (Q92843)
Bcl-2-like protein 2 (Bcl2-L-2) (Apoptosis regulator Bcl-W)
Gene: BCL2L2
Interactor 2: BAD (Q92934)
Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death)
Gene: BAD
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.93 | 1.00 | 0.968 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 20603619, 32296183, 11483855, 16697956, 15694340, 12115603, 10381646, 22000515, unassigned1304 |
| Identification Methods | affinity chromatography technology, two hybrid, pull down, unspecified method, isothermal titration calorimetry, two hybrid prey pooling approach, two hybrid array, validated two hybrid, surface plasmon resonance |
| Interaction Type | physical association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Bcl-2~Bcl-2_BAD |
| Common GO terms | GO:0005741 - mitochondrial outer membrane GO:0005829 - cytosol GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage GO:0097192 - extrinsic apoptotic signaling pathway in absence of ligand |
| Homologous interactions | 8 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
