HitPredict

Interactor 1: B2CL2 (Q92843)
Bcl-2-like protein 2 (Bcl2-L-2) (Apoptosis regulator Bcl-W)
Gene: BCL2L2

Interactor 2: BBC3 (Q9BXH1)
Bcl-2-binding component 3, isoforms 1/2 (JFY-1) (p53 up-regulated modulator of apoptosis)
Gene: BBC3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	28514442, 16697956, 15694340
Identification Methods	anti tag coimmunoprecipitation, fluorescence polarization spectroscopy, surface plasmon resonance
Interaction Type	association, direct interaction

Property	Details
Interacting Pfam domains	Bcl-2~PUMA
Common GO terms	GO:0005741 - mitochondrial outer membrane GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 193 Hs			1 193
+	Hs
		489454 BCL2_HUMAN (9-193): 1.75e-61: 192: 35.32		BBC3_HUMAN (1-193): 6.24e-98: 283: 100.00
+	Hs
		992123 B2CL1_HUMAN (6-185): 1.44e-56: 179: 38.96		BBC3_HUMAN (1-193): 6.24e-98: 283: 100.00
+	Mm
		1145397 B2CL1_MOUSE (6-185): 6.2e-56: 178: 38.96		BBC3_MOUSE (1-193): 1.53e-91: 267: 90.67
+	Hs
		992195 MCL1_HUMAN (19-180): 6.36e-46: 156: 21.82		BBC3_HUMAN (1-193): 6.24e-98: 283: 100.00
+	Hs
		1083081 B2LA1_HUMAN (20-152): 1.24e-41: 139: 19.29		BBC3_HUMAN (1-193): 6.24e-98: 283: 100.00
+	Mm
		956157 MCL1_MOUSE (19-180): 8.03e-45: 153: 23.03		BBC3_MOUSE (1-193): 1.53e-91: 267: 90.67
+	Mm
		991239 B2LA1_MOUSE (20-152): 4.5e-40: 136: 20.71		BBC3_MOUSE (1-193): 1.53e-91: 267: 90.67