HitPredict

Interactor 1: TANK (Q92844)
TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF)
Gene: TANK

Interactor 2: TRAF4 (Q9BUZ4)
TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83)
Gene: TRAF4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	30561431
Identification Methods	affinity chromatography technology, virotrap
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 425 Hs			1 470
+	Hs
		1020843 TANK_HUMAN (1-425): 0: 833: 100.00		TRAF2_HUMAN (2-465): 4.35e-117: 354: 29.86
+	Hs
		129583 TANK_HUMAN (1-425): 0: 833: 100.00		TRAF5_HUMAN (2-465): 7.74e-104: 322: 24.95
+	Mm
		761808 TANK_MOUSE (1-425): 0: 781: 79.58		TRAF2_MOUSE (2-465): 1.21e-117: 355: 30.06
+	Hs
		1024723 TANK_HUMAN (1-425): 0: 833: 100.00		TRAF3_HUMAN (3-465): 2.47e-92: 292: 22.99
+	Hs
		1271787 TANK_HUMAN (1-425): 0: 833: 100.00		TRAF6_HUMAN (3-464): 1.61e-84: 271: 24.79
+	Mm
		936633 TANK_MOUSE (1-425): 0: 781: 79.58		TRAF3_MOUSE (3-465): 4.11e-101: 315: 24.17
+	Hs
		1023743 TANK_HUMAN (1-425): 0: 833: 100.00		TRAF1_HUMAN (16-465): 6.07e-72: 235: 24.18
+	Mm
		761778 TANK_MOUSE (1-425): 0: 781: 79.58		TRAF1_MOUSE (80-465): 2.74e-79: 254: 23.34
+	Hs
		301951 TANK_HUMAN (1-425): 0: 833: 100.00		TRI37_HUMAN (5-465): 5.48e-55: 199: 13.81
+	Hs
		1271759 TANK_HUMAN (1-425): 0: 833: 100.00		RNF41_HUMAN (3-129): 4.01e-35: 135: 29.55