HitPredict

Interactor 1: CASPA (Q92851)
Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]
Gene: CASP10

Interactor 2: CASPA (Q92851)
Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]
Gene: CASP10

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.865

The method score is based on:

Property Details
Experiments 8962078, 8755496, 11717445
Identification Methods enzymatic study, protease assay, cross-linking study, fluorescent resonance energy transfer
Interaction Type direct interaction, protein cleavage, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains DED~DED, Peptidase_C14~Peptidase_C14
Common GO terms GO:0004197 - cysteine-type endopeptidase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006508 - proteolysis
GO:0006915 - apoptotic process
and 11 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 521
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024