HitPredict

Interactor 1: IPO5 (O00410)
Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5)
Gene: IPO5

Interactor 2: NU214 (P35658)
Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN)
Gene: NUP214

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	9114010, 37516964
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005643 - nuclear pore GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006606 - protein import into nucleus GO:0008139 - nuclear localization sequence binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1097 Hs			1 2090
+	Hs
		127176 IPO5_HUMAN (1-1097): 0: 784: 100.00		MUC1_HUMAN (409-1453): 4.37e-48: 191: 10.52
+	Hs
		727300 TNPO1_HUMAN (206-1095): 3.05e-72: 260: 11.83		NU214_HUMAN (1-2090): 0: 691: 100.00
+	Hs
		727254 IMB1_HUMAN (537-1094): 1.75e-11: 70.8: 11.11		NU214_HUMAN (1-2090): 0: 691: 100.00
+	Sc
		687987 IMB3_YEAST (1-1055): 7.64e-130: 424: 28.48		NU116_YEAST (1635-2087): 1.93e-21: 104: 19.54
+	Sc
		687969 IMB3_YEAST (1-1055): 7.64e-130: 424: 28.48		NU145_YEAST (1481-1847): 6.54e-16: 86.7: 15.82
+	Sc
		687986 IMB3_YEAST (1-1055): 7.64e-130: 424: 28.48		NU100_YEAST (1215-1810): 7.25e-11: 69.8: 13.32
+	Sc
		767713 IMB4_YEAST (6-1095): 1.28e-113: 381: 18.55		NU116_YEAST (1635-2087): 1.93e-21: 104: 19.54
+	Sc
		767712 IMB4_YEAST (6-1095): 1.28e-113: 381: 18.55		NU100_YEAST (1215-1810): 7.25e-11: 69.8: 13.32
+	Xl
		1137359 Q5U4V0_XENLA (206-1095): 4.2e-69: 251: 11.50		NU153_XENLA (768-2082): 9.36e-35: 148: 14.95
+	Hs
		858024 TNPO1_HUMAN (206-1095): 3.05e-72: 260: 11.83		NUP98_HUMAN (1481-1973): 9.16e-17: 89.7: 15.60
+	Tt
		101907 G0SGZ5_CHATD (22-798): 2.18e-70: 255: 19.06		NU145_CHATD (1121-1948): 5.4e-17: 90.2: 14.65
+	Hs
		155553 TNPO2_HUMAN (200-1095): 2.78e-70: 254: 12.49		NUP98_HUMAN (1481-1973): 9.16e-17: 89.7: 15.60
+	Sc
		971907 IMB1_YEAST (9-762): 6.36e-60: 223: 15.79		NU116_YEAST (1635-2087): 1.93e-21: 104: 19.54
+	Sc
		830681 IMB1_YEAST (9-762): 6.36e-60: 223: 15.79		NU145_YEAST (1481-1847): 6.54e-16: 86.7: 15.82
+	Sc
		971878 IMB1_YEAST (9-762): 6.36e-60: 223: 15.79		NU100_YEAST (1215-1810): 7.25e-11: 69.8: 13.32
+	Hs
		1056831 IMB1_HUMAN (537-1094): 1.75e-11: 70.8: 11.11		MDC1_HUMAN (423-1348): 9.84e-37: 155: 10.01
+	Hs
		857978 IMB1_HUMAN (537-1094): 1.75e-11: 70.8: 11.11		NUP98_HUMAN (1481-1973): 9.16e-17: 89.7: 15.60
+	Hs
		1060882 IMB1_HUMAN (537-1094): 1.75e-11: 70.8: 11.11		CIC_HUMAN (242-1032): 8.51e-14: 79.9: 9.89
+	Xl
		853820 IMB_XENLA (537-1094): 1.43e-11: 70.8: 11.22		Q6DCP4_XENLA (1491-1969): 7.76e-09: 62.8: 13.33