HitPredict

Interactor 1: RAD50 (Q92878)
DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-)
Gene: RAD50

Interactor 2: CIC (Q96RK0)
Protein capicua homolog
Gene: CIC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	30021884, 29844126
Identification Methods	proximity labelling technology, affinity chromatography technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1312 Hs			1 2517
+	Hs
		1057362 SMC1A_HUMAN (290-1274): 4.82e-19: 95.7: 11.17		CIC_HUMAN (1-2517): 0: 961: 100.00
+	Hs
		1300969 DAPLE_HUMAN (420-1089): 3.01e-18: 93.5: 13.59		CIC_HUMAN (1-2517): 0: 961: 100.00
+	Hs
		551812 DESP_HUMAN (190-1069): 1.96e-10: 67.8: 18.71		CIC_HUMAN (1-2517): 0: 961: 100.00
+	Hs
		1056911 RAD50_HUMAN (1-1312): 1.28e-115: 394: 100.00		MDC1_HUMAN (1380-2408): 4.76e-21: 104: 10.30
+	Hs
		818047 SMC1A_HUMAN (290-1274): 4.82e-19: 95.7: 11.17		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Mm
		818762 SMC1A_MOUSE (290-1274): 4e-19: 96.1: 11.16		SOX2_MOUSE (1102-1308): 3.32e-55: 198: 26.44
+	Hs
		725110 MYH10_HUMAN (44-596): 1.31e-16: 88.3: 13.20		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Hs
		551635 DESP_HUMAN (190-1069): 1.96e-10: 67.8: 18.71		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Hs
		148522 CTRO_HUMAN (732-1116): 8.66e-10: 65.7: 12.15		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Hs
		725013 MYH9_HUMAN (474-1226): 2.43e-26: 119: 10.19		TARA_HUMAN (523-2026): 3.76e-17: 91.1: 11.33
+	Hs
		1056828 SMC1A_HUMAN (290-1274): 4.82e-19: 95.7: 11.17		MDC1_HUMAN (1380-2408): 4.76e-21: 104: 10.30
+	Hs
		1268090 MY18A_HUMAN (158-674): 1.53e-19: 97.7: 14.45		TARA_HUMAN (523-2026): 3.76e-17: 91.1: 11.33
+	Hs
		724893 MYH9_HUMAN (474-1226): 2.43e-26: 119: 10.19		MICA3_HUMAN (2116-2494): 3.95e-09: 64.7: 11.35
+	Hs
		724782 MYH9_HUMAN (474-1226): 2.43e-26: 119: 10.19		ANK2_HUMAN (535-2225): 4.48e-09: 64.6: 9.78
+	Hs
		148818 CTRO_HUMAN (732-1116): 8.66e-10: 65.7: 12.15		MDC1_HUMAN (1380-2408): 4.76e-21: 104: 10.30
+	Hs
		1057291 SMC1A_HUMAN (290-1274): 4.82e-19: 95.7: 11.17		ANR11_HUMAN (1833-2514): 2.6e-11: 72.1: 12.66
+	Hs
		1186077 MY18A_HUMAN (158-674): 1.53e-19: 97.7: 14.45		MICA3_HUMAN (2116-2494): 3.95e-09: 64.7: 11.35
+	Hs
		1057338 SMC1A_HUMAN (290-1274): 4.82e-19: 95.7: 11.17		TITIN_HUMAN (609-1544): 3.51e-09: 65.2: 9.85
+	Hs
		725139 MYH10_HUMAN (44-596): 1.31e-16: 88.3: 13.20		ANK2_HUMAN (535-2225): 4.48e-09: 64.6: 9.78
+	Hs
		551790 DESP_HUMAN (190-1069): 1.96e-10: 67.8: 18.71		TITIN_HUMAN (609-1544): 3.51e-09: 65.2: 9.85