HitPredict

Interactor 1: M4K1 (Q92918)
Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)
Gene: MAP4K1

Interactor 2: KBRS2 (Q9NYR9)
NF-kappa-B inhibitor-interacting Ras-like protein 2 (I-kappa-B-interacting Ras-like protein 2) (Kappa B-Ras protein 2) (KappaB-Ras2)
Gene: NKIRAS2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	32640226
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 833 Hs			1 191
+	Hs
		894759 M4K3_HUMAN (7-820): 0: 863: 38.76		RAB8A_HUMAN (1-187): 2.04e-77: 231: 23.04
+	Hs
		914488 M4K5_HUMAN (7-820): 0: 864: 44.15		RB11A_HUMAN (5-183): 5.92e-70: 213: 24.02
+	Hs
		894728 M4K2_HUMAN (7-820): 0: 769: 40.72		RAB8A_HUMAN (1-187): 2.04e-77: 231: 23.04
+	Hs
		349139 MARK3_HUMAN (14-595): 2.5e-139: 432: 17.20		RASH_HUMAN (17-190): 5.34e-75: 225: 25.29
+	Hs
		647857 MARK3_HUMAN (14-595): 2.5e-139: 432: 17.20		RAB2A_HUMAN (5-185): 3.43e-71: 216: 19.89
+	Hs
		647864 MARK3_HUMAN (14-595): 2.5e-139: 432: 17.20		RB11A_HUMAN (5-183): 5.92e-70: 213: 24.02
+	Hs
		349425 MARK2_HUMAN (14-597): 8.02e-134: 419: 16.86		RASH_HUMAN (17-190): 5.34e-75: 225: 25.29
+	Hs
		895142 MARK2_HUMAN (14-597): 8.02e-134: 419: 16.86		RAB2A_HUMAN (5-185): 3.43e-71: 216: 19.89
+	Hs
		914159 MARK2_HUMAN (14-597): 8.02e-134: 419: 16.86		RB11A_HUMAN (5-183): 5.92e-70: 213: 24.02
+	Hs
		682159 AKT2_HUMAN (1-337): 6.85e-129: 396: 23.19		RAB2A_HUMAN (5-185): 3.43e-71: 216: 19.89
+	Hs
		894729 STK4_HUMAN (4-437): 2.54e-121: 376: 33.10		RAB8A_HUMAN (1-187): 2.04e-77: 231: 23.04
+	Hs
		894835 STK24_HUMAN (9-295): 4.54e-116: 361: 42.36		RAB8A_HUMAN (1-187): 2.04e-77: 231: 23.04
+	Dm
		442965 HIPPO_DROME (13-289): 5.89e-110: 353: 43.17		RAP1_DROME (3-169): 1.52e-80: 238: 27.55
+	Hs
		296405 STK10_HUMAN (12-540): 3.77e-111: 364: 28.55		RB11A_HUMAN (5-183): 5.92e-70: 213: 24.02
+	Hs
		914500 STK24_HUMAN (9-295): 4.54e-116: 361: 42.36		RB11A_HUMAN (5-183): 5.92e-70: 213: 24.02
+	Hs
		349719 TNIK_HUMAN (11-296): 3.35e-64: 236: 42.57		RASH_HUMAN (17-190): 5.34e-75: 225: 25.29
+	Hs
		681973 AKT1_HUMAN (1-337): 6.85e-129: 396: 23.12		RHES_HUMAN (4-175): 7.37e-11: 61.2: 30.69
+	Hs
		349478 MINK1_HUMAN (11-296): 6.63e-61: 226: 43.58		RASH_HUMAN (17-190): 5.34e-75: 225: 25.29