HitPredict

Interactor 1: IPO5 (O00410)
Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5)
Gene: IPO5

Interactor 2: MIRO2 (Q8IXI1)
Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2)
Gene: RHOT2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	32877691, 33961781, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Importin_rep_4~Ras
Common GO terms	GO:0016020 - membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1097 Hs			1 618
+	Hs
		127315 IPO5_HUMAN (1-1097): 0: 784: 100.00		MIRO1_HUMAN (1-618): 0: 763: 59.65
+	Hs
		236437 RNBP6_HUMAN (7-1097): 0: 726: 79.56		MIRO2_HUMAN (1-618): 0: 792: 100.00
+	Hs
		127230 IPO5_HUMAN (1-1097): 0: 784: 100.00		CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54
+	Hs
		236414 RNBP6_HUMAN (7-1097): 0: 726: 79.56		RB11A_HUMAN (416-572): 8.23e-22: 96.2: 20.37
+	Hs
		894245 IPO4_HUMAN (21-1097): 1.13e-110: 372: 19.33		CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54
+	Hs
		925464 IPO4_HUMAN (21-1097): 1.13e-110: 372: 19.33		RAC1_HUMAN (3-181): 3.15e-74: 237: 26.43
+	Hs
		925496 TNPO1_HUMAN (206-1095): 3.05e-72: 260: 11.83		RAC1_HUMAN (3-181): 3.15e-74: 237: 26.43
+	Hs
		900728 IPO4_HUMAN (21-1097): 1.13e-110: 372: 19.33		RHOA_HUMAN (6-168): 1.74e-11: 65.5: 28.25
+	Mm
		1206345 TNPO1_MOUSE (206-1095): 5.52e-72: 259: 11.72		RAB13_MOUSE (411-571): 1.89e-27: 111: 18.07
+	Hs
		925285 IMB1_HUMAN (537-1094): 1.75e-11: 70.8: 11.11		RAC1_HUMAN (3-181): 3.15e-74: 237: 26.43