HitPredict

Interactor 1: ARHG2 (Q92974)
Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)
Gene: ARHGEF2

Interactor 2: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~RhoGEF
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 986 Hs			1 779
+	Hs
		1170401 ARHGI_HUMAN (1-982): 5.42e-125: 414: 30.77		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1273280 ARHG2_HUMAN (1-986): 0: 736: 100.00		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		1331486 ARHGC_HUMAN (64-975): 7.9e-104: 357: 16.93		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		855823 VAV2_HUMAN (40-788): 3.5e-103: 344: 13.46		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1272198 ARHG1_HUMAN (31-698): 5.2e-86: 298: 21.49		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		855792 VAV2_HUMAN (40-788): 3.5e-103: 344: 13.46		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Ce
		136804 VAV_CAEEL (35-839): 2.53e-91: 315: 12.97		UNC89_CAEEL (146-660): 3.62e-58: 218: 12.35
+	Hs
		1035413 VAV3_HUMAN (40-828): 1.15e-98: 331: 12.49		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Mm
		1194490 ARHG7_MOUSE (22-851): 9.73e-95: 321: 12.00		CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40
+	Hs
		1022406 TIAM1_HUMAN (14-814): 3.23e-87: 309: 16.14		PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02
+	Hs
		548703 VAV_HUMAN (142-680): 1.01e-84: 293: 15.54		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Hs
		167092 ARHGB_HUMAN (109-915): 6.47e-88: 311: 21.18		MPRIP_HUMAN (2-499): 4.76e-44: 173: 16.57
+	Hs
		548722 VAV_HUMAN (142-680): 1.01e-84: 293: 15.54		CYTSA_HUMAN (320-643): 3.92e-43: 171: 12.81
+	Mm
		57863 KALRN_MOUSE (224-886): 3.77e-76: 276: 12.32		CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40
+	Hs
		200789 ARHG9_HUMAN (162-599): 2.49e-92: 305: 12.45		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		1127536 FGD3_HUMAN (94-769): 6.53e-90: 304: 15.08		RHG22_HUMAN (29-181): 1.62e-33: 139: 26.95
+	Mm
		57840 KALRN_MOUSE (224-886): 3.77e-76: 276: 12.32		CYTSA_MOUSE (320-643): 7.93e-41: 164: 12.20
+	Hs
		299235 VAV_HUMAN (142-680): 1.01e-84: 293: 15.54		FARP2_HUMAN (5-183): 2.45e-30: 130: 21.69
+	Hs
		299283 Q96D37_HUMAN (142-680): 2.9e-85: 293: 15.54		FARP2_HUMAN (5-183): 2.45e-30: 130: 21.69