HitPredict

Interactor 1: ARHG2 (Q92974)
Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)
Gene: ARHGEF2

Interactor 2: PAK5 (Q9P286)
Serine/threonine-protein kinase PAK 5 (EC 2.7.11.1) (p21-activated kinase 5) (PAK-5) (p21-activated kinase 7) (PAK-7)
Gene: PAK5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 986 Hs			1 719
+	Hs
		166594 ARHG2_HUMAN (1-986): 0: 736: 100.00		DCLK1_HUMAN (93-719): 1.75e-136: 421: 19.47
+	Hs
		167116 ARHGB_HUMAN (109-915): 6.47e-88: 311: 21.18		PAK5_HUMAN (1-719): 0: 673: 100.00
+	Hs
		331058 ARHG2_HUMAN (1-986): 0: 736: 100.00		PAK4_HUMAN (1-314): 7.21e-41: 160: 28.35
+	Hs
		1026200 ARHG2_HUMAN (1-986): 0: 736: 100.00		PAK1_HUMAN (3-183): 1.54e-28: 122: 18.69
+	Hs
		681936 ARG28_HUMAN (11-875): 8.11e-130: 432: 35.80		AKT1_HUMAN (307-716): 1.36e-131: 399: 19.77
+	Hs
		166557 TIAM1_HUMAN (14-814): 3.23e-87: 309: 16.14		DCLK1_HUMAN (93-719): 1.75e-136: 421: 19.47
+	Hs
		850719 ARHGC_HUMAN (64-975): 7.9e-104: 357: 16.93		KS6A3_HUMAN (386-714): 3.35e-112: 357: 22.41
+	Hs
		855832 VAV2_HUMAN (40-788): 3.5e-103: 344: 13.46		STK24_HUMAN (416-717): 5.17e-118: 363: 36.18
+	Hs
		1073489 ARHGC_HUMAN (64-975): 7.9e-104: 357: 16.93		KS6A1_HUMAN (386-714): 2.98e-109: 349: 22.03
+	Hs
		681894 ARHGG_HUMAN (111-623): 6.11e-82: 282: 18.06		AKT1_HUMAN (307-716): 1.36e-131: 399: 19.77
+	Hs
		167086 ARHGB_HUMAN (109-915): 6.47e-88: 311: 21.18		KS6A1_HUMAN (386-714): 2.98e-109: 349: 22.03
+	Hs
		1026910 ARHG6_HUMAN (22-797): 1.34e-103: 343: 11.48		PAK2_HUMAN (8-157): 1.07e-30: 129: 20.99
+	Hs
		167057 ARHGB_HUMAN (109-915): 6.47e-88: 311: 21.18		PAK4_HUMAN (1-314): 7.21e-41: 160: 28.35
+	Hs
		1026167 ARHG6_HUMAN (22-797): 1.34e-103: 343: 11.48		PAK1_HUMAN (3-183): 1.54e-28: 122: 18.69
+	Hs
		1026904 ARHG7_HUMAN (22-779): 1.98e-100: 335: 11.77		PAK2_HUMAN (8-157): 1.07e-30: 129: 20.99
+	Hs
		277605 ARHG7_HUMAN (22-779): 1.98e-100: 335: 11.77		PAK3_HUMAN (3-189): 9.13e-31: 129: 19.43
+	Hs
		1026158 ARHG7_HUMAN (22-779): 1.98e-100: 335: 11.77		PAK1_HUMAN (3-183): 1.54e-28: 122: 18.69
+	Mm
		1142068 ARHG7_MOUSE (22-851): 9.73e-95: 321: 12.00		PAK3_MOUSE (3-189): 1.91e-30: 128: 19.91
+	Hs
		81635 B7Z6G2_HUMAN (91-795): 2.19e-94: 316: 11.75		PAK2_HUMAN (8-157): 1.07e-30: 129: 20.99
+	Mm
		292047 ARHG7_MOUSE (22-851): 9.73e-95: 321: 12.00		PAK1_MOUSE (3-183): 2.49e-28: 122: 18.69