HitPredict

Interactor 1: UBP13 (Q92995)
Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.4.19.12) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13)
Gene: USP13

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	19615732
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0044389 - ubiquitin-like protein ligase binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 863 Hs			1 903
+	Hs
		800615 UBP5_HUMAN (26-863): 0: 740: 59.93		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		125223 UBP5_HUMAN (26-863): 0: 740: 59.93		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		1273700 USP9X_HUMAN (296-701): 3.34e-69: 252: 16.86		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		125794 UBP24_HUMAN (295-815): 1.35e-78: 281: 13.40		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		1273724 USP9X_HUMAN (296-701): 3.34e-69: 252: 16.86		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		125624 USP9X_HUMAN (296-701): 3.34e-69: 252: 16.86		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		64219 UBP27_HUMAN (706-860): 3.58e-13: 74.6: 12.07		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		800630 UBP5_HUMAN (26-863): 0: 740: 59.93		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Mm
		880550 UBP5_MOUSE (26-863): 0: 744: 60.51		SMUF1_MOUSE (1-535): 3.62e-41: 164: 14.07
+	Hs
		1192153 USP9X_HUMAN (296-701): 3.34e-69: 252: 16.86		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		1173813 UBP49_HUMAN (188-333): 2.18e-26: 117: 20.55		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		1174162 UBP50_HUMAN (328-614): 3.34e-24: 106: 17.63		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		1024370 UBP4_HUMAN (460-606): 2.3e-11: 69.8: 16.34		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		1273741 USP9X_HUMAN (296-701): 3.34e-69: 252: 16.86		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Hs
		1273751 USP9X_HUMAN (296-701): 3.34e-69: 252: 16.86		HECW2_HUMAN (1-512): 1.38e-13: 77.2: 11.34
+	Mm
		292021 UBP2_MOUSE (713-859): 3.01e-23: 107: 16.45		NEDD4_MOUSE (13-426): 2.27e-52: 199: 18.38
+	Hs
		1350500 UBP21_HUMAN (718-859): 5.38e-25: 112: 18.62		HECW2_HUMAN (1-512): 1.38e-13: 77.2: 11.34