HitPredict

Interactor 1: DVL3 (Q92997)
Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3)
Gene: DVL3

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	28455968, 22826439
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 716 Hs			1 903
+	Hs
		150747 DVL1_HUMAN (1-716): 8.84e-151: 456: 63.66		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		1273633 DVL3_HUMAN (1-716): 1.38e-173: 515: 100.00		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		151140 DVL2_HUMAN (3-716): 2.33e-133: 412: 65.13		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		150752 DVL1_HUMAN (1-716): 8.84e-151: 456: 63.66		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		124995 DVL1_HUMAN (1-716): 8.84e-151: 456: 63.66		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		151182 DVL2_HUMAN (3-716): 2.33e-133: 412: 65.13		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		124996 DVL2_HUMAN (3-716): 2.33e-133: 412: 65.13		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		151146 DVL2_HUMAN (3-716): 2.33e-133: 412: 65.13		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		150684 DVL1_HUMAN (1-716): 8.84e-151: 456: 63.66		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		1192152 DVL3_HUMAN (1-716): 1.38e-173: 515: 100.00		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		150725 DVL1_HUMAN (1-716): 8.84e-151: 456: 63.66		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Mm
		93273 DLG4_MOUSE (91-649): 6.72e-43: 167: 13.22		E9PXB7_MOUSE (86-900): 0: 654: 34.22
+	Hs
		1021523 DLG1_HUMAN (113-656): 1.76e-42: 167: 14.34		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Mm
		56824 DVL1_MOUSE (1-716): 3.66e-157: 473: 62.83		SMUF2_MOUSE (1-358): 2.99e-46: 179: 16.67
+	Mm
		56830 DVL2_MOUSE (3-716): 2.64e-136: 420: 64.80		SMUF2_MOUSE (1-358): 2.99e-46: 179: 16.67
+	Hs
		151206 DVL2_HUMAN (3-716): 2.33e-133: 412: 65.13		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Hs
		151200 DVL2_HUMAN (3-716): 2.33e-133: 412: 65.13		SMUF2_HUMAN (1-358): 2.56e-46: 180: 16.94
+	Mm
		1141509 DVL2_MOUSE (3-716): 2.64e-136: 420: 64.80		SMUF1_MOUSE (1-535): 3.62e-41: 164: 14.07
+	Hs
		150723 DVL1_HUMAN (1-716): 8.84e-151: 456: 63.66		HECW1_HUMAN (26-479): 2.25e-13: 76.9: 10.76
+	Ce
		1094742 MIG5_CAEEL (2-545): 2.14e-57: 208: 26.29		Q9BKW4_CAEEL (319-581): 6.75e-13: 74.2: 16.33