HitPredict

Interactor 1: DVL3 (Q92997)
Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3)
Gene: DVL3

Interactor 2: VANG2 (Q9ULK5)
Vang-like protein 2 (Loop-tail protein 1 homolog) (Strabismus 1) (Van Gogh-like protein 2)
Gene: VANGL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0060071 - Wnt signaling pathway, planar cell polarity pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 716 Hs			1 521
+	Hs
		1250791 DVL3_HUMAN (1-716): 1.38e-173: 515: 100.00		VANG1_HUMAN (21-521): 0: 780: 72.87
+	Mm
		1142090 DVL3_MOUSE (1-716): 4.23e-172: 512: 99.02		VANG1_MOUSE (21-521): 0: 765: 71.60
+	Mm
		844428 DVL1_MOUSE (1-716): 3.66e-157: 473: 62.83		VANG1_MOUSE (21-521): 0: 765: 71.60
+	Mm
		1142094 DVL3_MOUSE (1-716): 4.23e-172: 512: 99.02		VANG2_MOUSE (1-521): 0: 724: 99.42
+	Mm
		844432 DVL1_MOUSE (1-716): 3.66e-157: 473: 62.83		VANG2_MOUSE (1-521): 0: 724: 99.42
+	Hs
		151096 DVL2_HUMAN (3-716): 2.33e-133: 412: 65.13		VANG1_HUMAN (21-521): 0: 780: 72.87
+	Mm
		1141500 DVL2_MOUSE (3-716): 2.64e-136: 420: 64.80		VANG1_MOUSE (21-521): 0: 765: 71.60
+	Mm
		1141507 DVL2_MOUSE (3-716): 2.64e-136: 420: 64.80		VANG2_MOUSE (1-521): 0: 724: 99.42
+	Hs
		151251 DVL2_HUMAN (3-716): 2.33e-133: 412: 65.13		VANG2_HUMAN (1-521): 0: 725: 100.00
+	Dm
		219854 DSH_DROME (3-558): 5.64e-101: 324: 46.13		O45030_DROME (16-521): 0: 677: 43.91
+	Dm
		52640 DSH_DROME (3-558): 5.64e-101: 324: 46.13		A1Z7N9_DROME (16-521): 0: 677: 43.91
+	Ce
		109389 Q18239_CAEEL (4-626): 4.09e-89: 297: 31.14		H2KY90_CAEEL (2-521): 0: 652: 30.24
+	Hs
		1021536 DLG1_HUMAN (113-656): 1.76e-42: 167: 14.34		VANG1_HUMAN (21-521): 0: 780: 72.87
+	Mm
		1143382 DLG4_MOUSE (91-649): 6.72e-43: 167: 13.22		VANG1_MOUSE (21-521): 0: 765: 71.60
+	Hs
		1021588 DLG1_HUMAN (113-656): 1.76e-42: 167: 14.34		VANG2_HUMAN (1-521): 0: 725: 100.00
+	Mm
		1143470 DLG4_MOUSE (91-649): 6.72e-43: 167: 13.22		VANG2_MOUSE (1-521): 0: 724: 99.42
+	Rn
		677774 DLG4_RAT (91-649): 1.39e-42: 166: 13.19		VANG2_RAT (1-521): 0: 724: 99.42
+	Hs
		1250786 PARD3_HUMAN (200-415): 1.34e-19: 96.2: 20.00		VANG1_HUMAN (21-521): 0: 780: 72.87
+	Mm
		1193536 SCRIB_MOUSE (57-647): 2.05e-26: 118: 14.50		VANG2_MOUSE (1-521): 0: 724: 99.42
+	Hs
		1256921 PARD3_HUMAN (200-415): 1.34e-19: 96.2: 20.00		VANG2_HUMAN (1-521): 0: 725: 100.00