HitPredict

Interactor 1: USP9X (Q93008)
Ubiquitin carboxyl-terminal hydrolase 9X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets in mammals) (hFAM) (Fat facets protein-related, X-linked) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)
Gene: USP9X

Interactor 2: WWP1 (Q9H0M0)
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
Gene: WWP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	31340145, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 2554 Hs			1 922
+	Hs
		1273700 USP9X_HUMAN (1-2554): 0: 3676: 100.00		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Hs
		125624 USP9X_HUMAN (1-2554): 0: 3676: 100.00		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		1192153 USP9X_HUMAN (1-2554): 0: 3676: 100.00		HUWE1_HUMAN (130-921): 1.4e-172: 559: 24.48
+	Hs
		1273741 USP9X_HUMAN (1-2554): 0: 3676: 100.00		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82
+	Hs
		1273751 USP9X_HUMAN (1-2554): 0: 3676: 100.00		HECW2_HUMAN (141-582): 1.9e-12: 73.8: 16.11
+	Hs
		125794 UBP24_HUMAN (36-2478): 0: 2211: 29.78		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		64219 UBP27_HUMAN (1524-1949): 2.29e-96: 321: 17.61		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Hs
		259303 UBP12_HUMAN (1519-1957): 8.45e-94: 311: 21.51		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Hs
		125625 UBP7_HUMAN (1469-2119): 8.05e-96: 339: 18.82		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		1273807 UBP7_HUMAN (1469-2119): 8.05e-96: 339: 18.82		NED4L_HUMAN (1-919): 0: 822: 33.16
+	Hs
		1192154 UBP7_HUMAN (1469-2119): 8.05e-96: 339: 18.82		HUWE1_HUMAN (130-921): 1.4e-172: 559: 24.48
+	Mm
		1149452 UBP7_MOUSE (1469-2119): 1.12e-95: 339: 18.82		HUWE1_MOUSE (130-921): 2.15e-172: 558: 24.29
+	Hs
		1176343 UBP7_HUMAN (1469-2119): 8.05e-96: 339: 18.82		HECW1_HUMAN (163-530): 4.01e-13: 76.1: 18.40