HitPredict

Interactor 1: UBP7 (Q93009)
Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7)
Gene: USP7

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	31666375, 18952891, 11279055, 20622874
Identification Methods	affinity chromatography technology, pull down, enzymatic study, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0032991 - protein-containing complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1102 Hs			1 522
+	Hs
		1020848 UBP7_HUMAN (1-1102): 0: 1165: 100.00		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		1273839 UBP7_HUMAN (1-1102): 0: 1165: 100.00		TRAF4_HUMAN (54-500): 6.36e-91: 287: 26.11
+	Hs
		129585 UBP7_HUMAN (1-1102): 0: 1165: 100.00		TRAF5_HUMAN (43-500): 4.95e-87: 280: 25.23
+	Hs
		1024726 UBP7_HUMAN (1-1102): 0: 1165: 100.00		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Hs
		1023747 UBP7_HUMAN (1-1102): 0: 1165: 100.00		TRAF1_HUMAN (50-501): 5.58e-64: 216: 19.40
+	Hs
		1273788 UBP7_HUMAN (1-1102): 0: 1165: 100.00		TRI11_HUMAN (59-404): 1.13e-49: 179: 12.75
+	Hs
		536961 UBP7_HUMAN (1-1102): 0: 1165: 100.00		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		1223388 UBP7_HUMAN (1-1102): 0: 1165: 100.00		TRI22_HUMAN (56-361): 5.96e-39: 150: 15.51
+	Hs
		1273857 UBP7_HUMAN (1-1102): 0: 1165: 100.00		TRI31_HUMAN (58-334): 3.02e-35: 138: 15.00
+	Hs
		1295925 UBP47_HUMAN (208-737): 3.48e-107: 368: 26.62		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Mm
		936251 UBP47_MOUSE (167-737): 1.59e-103: 357: 24.61		TRAF6_MOUSE (1-522): 5.7e-141: 418: 87.93
+	Hs
		1020772 UBP48_HUMAN (206-572): 1.45e-102: 349: 26.90		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		1020743 U17L2_HUMAN (158-684): 1.09e-103: 338: 19.05		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		1024738 UBP47_HUMAN (208-737): 3.48e-107: 368: 26.62		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Hs
		1024693 U17L2_HUMAN (158-684): 1.09e-103: 338: 19.05		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Hs
		1295898 UBP47_HUMAN (208-737): 3.48e-107: 368: 26.62		TRI31_HUMAN (58-334): 3.02e-35: 138: 15.00
+	Hs
		1019375 UBP36_HUMAN (165-651): 1.45e-94: 328: 18.13		TRI26_HUMAN (61-410): 2.85e-38: 149: 14.59
+	Hs
		1252377 USP9X_HUMAN (173-554): 7.42e-97: 341: 23.08		LNX1_HUMAN (58-183): 2.59e-11: 68.3: 19.84