HitPredict

Interactor 1: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Interactor 2: UBE2F (Q969M7)
NEDD8-conjugating enzyme UBE2F (EC 2.3.2.32) (NEDD8 carrier protein UBE2F) (NEDD8 protein ligase UBE2F) (NEDD8-conjugating enzyme 2) (RING-type E3 NEDD8 transferase UBE2F) (Ubiquitin-conjugating enzyme E2 F)
Gene: UBE2F

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.882

Property	Details
Experiments	27591266, 33712558, 22190037, 23300442
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Cullin_Nedd8~UQ_con
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 780 Hs			1 185
+	Hs
		849325 CUL3_HUMAN (8-780): 0: 754: 22.96		UB2D1_HUMAN (32-184): 8.75e-74: 220: 32.03
+	Hs
		919724 CUL3_HUMAN (8-780): 0: 754: 22.96		UB2D2_HUMAN (32-184): 5.23e-74: 220: 32.03
+	Hs
		1042304 CUL3_HUMAN (8-780): 0: 754: 22.96		UB2E2_HUMAN (9-184): 1.68e-71: 216: 27.27
+	Hs
		851812 CUL3_HUMAN (8-780): 0: 754: 22.96		UB2E1_HUMAN (9-184): 5.43e-70: 212: 27.27
+	Hs
		1042223 CUL3_HUMAN (8-780): 0: 754: 22.96		UB2E3_HUMAN (15-184): 2.12e-69: 211: 28.82
+	Hs
		849326 CUL4A_HUMAN (16-780): 0: 744: 24.48		UB2D1_HUMAN (32-184): 8.75e-74: 220: 32.03
+	Hs
		895791 CUL4A_HUMAN (16-780): 0: 744: 24.48		UB2D3_HUMAN (32-184): 2.78e-72: 216: 31.37
+	Hs
		1041136 CUL1_HUMAN (11-780): 0: 748: 27.84		UB2E3_HUMAN (15-184): 2.12e-69: 211: 28.82
+	Hs
		1043149 CUL4A_HUMAN (16-780): 0: 744: 24.48		UB2E3_HUMAN (15-184): 2.12e-69: 211: 28.82
+	Hs
		1041134 CUL1_HUMAN (11-780): 0: 748: 27.84		UBE2F_HUMAN (1-185): 3.02e-67: 205: 100.00
+	Hs
		895792 CUL4B_HUMAN (16-780): 0: 736: 25.39		UB2D3_HUMAN (32-184): 2.78e-72: 216: 31.37
+	Hs
		828994 CUL4B_HUMAN (16-780): 0: 736: 25.39		UBE2A_HUMAN (30-185): 1.58e-65: 199: 22.44
+	Hs
		849324 CUL2_HUMAN (6-780): 0: 699: 26.36		UB2D1_HUMAN (32-184): 8.75e-74: 220: 32.03
+	Hs
		896175 CUL5_HUMAN (1-780): 0: 792: 100.00		UBC12_HUMAN (15-176): 1.42e-33: 119: 39.51
+	Hs
		896074 CUL3_HUMAN (8-780): 0: 754: 22.96		UBC12_HUMAN (15-176): 1.42e-33: 119: 39.51
+	Hs
		896072 CUL1_HUMAN (11-780): 0: 748: 27.84		UBC12_HUMAN (15-176): 1.42e-33: 119: 39.51
+	Hs
		896075 CUL4A_HUMAN (16-780): 0: 744: 24.48		UBC12_HUMAN (15-176): 1.42e-33: 119: 39.51
+	Dm
		1213851 Q8IP45_DROME (5-780): 0: 736: 22.73		UBC2M_DROME (9-181): 7.12e-34: 120: 38.73
+	Hs
		896076 CUL4B_HUMAN (16-780): 0: 736: 25.39		UBC12_HUMAN (15-176): 1.42e-33: 119: 39.51
+	At
		1277342 CUL1_ARATH (8-780): 0: 721: 24.34		RCE1_ARATH (17-162): 2.13e-28: 105: 38.78