HitPredict

Interactor 1: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Interactor 2: ASB9 (Q96DX5)
Ankyrin repeat and SOCS box protein 9 (ASB-9)
Gene: ASB9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.962

Property	Details
Experiments	23806657, 26186194, 28514442, 33961781, 20302626, 17148442, 23837592, 24337577
Identification Methods	x-ray crystallography, affinity chromatography technology, biochemical, anti tag coimmunoprecipitation
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 780 Hs			1 294
+	Hs
		1264015 CUL5_HUMAN (1-780): 0: 792: 100.00		ASB13_HUMAN (37-293): 3.65e-75: 232: 42.25
+	Hs
		556700 CUL3_HUMAN (8-780): 0: 754: 22.96		ANK1_HUMAN (4-294): 1.59e-76: 255: 20.86
+	Hs
		1042160 CUL3_HUMAN (8-780): 0: 754: 22.96		ASB13_HUMAN (37-293): 3.65e-75: 232: 42.25
+	Hs
		883509 CUL1_HUMAN (11-780): 0: 748: 27.84		RIPK4_HUMAN (3-289): 4.7e-66: 222: 22.26
+	Hs
		1041199 CUL1_HUMAN (11-780): 0: 748: 27.84		Q9H4D1_HUMAN (3-289): 1.34e-65: 220: 21.92
+	Hs
		1262947 CUL5_HUMAN (1-780): 0: 792: 100.00		ASB5_HUMAN (132-289): 6.21e-27: 109: 22.36
+	Hs
		1042562 CUL3_HUMAN (8-780): 0: 754: 22.96		EHMT1_HUMAN (29-180): 8.72e-38: 143: 26.62
+	Hs
		166925 CUL3_HUMAN (8-780): 0: 754: 22.96		ANR28_HUMAN (135-290): 3.44e-36: 139: 19.50
+	Hs
		1263828 CUL5_HUMAN (1-780): 0: 792: 100.00		ASB11_HUMAN (110-287): 5.49e-23: 98.3: 20.99
+	Hs
		1274048 CUL5_HUMAN (1-780): 0: 792: 100.00		ASB7_HUMAN (121-284): 1.03e-22: 97.2: 20.47
+	Hs
		1274095 CUL5_HUMAN (1-780): 0: 792: 100.00		ASB3_HUMAN (37-219): 1.2e-20: 93.6: 31.25
+	Hs
		1173122 CUL5_HUMAN (1-780): 0: 792: 100.00		ASB18_HUMAN (38-236): 6.25e-20: 91.3: 34.29
+	Hs
		1274096 CUL5_HUMAN (1-780): 0: 792: 100.00		ASB1_HUMAN (38-293): 9.83e-20: 89.4: 29.24
+	Hs
		1021397 CUL3_HUMAN (8-780): 0: 754: 22.96		ANK3_HUMAN (173-291): 4e-31: 124: 13.12
+	Hs
		1021398 CUL4A_HUMAN (16-780): 0: 744: 24.48		ANK3_HUMAN (173-291): 4e-31: 124: 13.12
+	Hs
		862036 CUL3_HUMAN (8-780): 0: 754: 22.96		DAPK1_HUMAN (4-130): 3.59e-26: 110: 17.97
+	Hs
		1274023 CUL5_HUMAN (1-780): 0: 792: 100.00		ASB2_HUMAN (72-254): 4e-10: 62.4: 28.34
+	Hs
		1043332 CUL4A_HUMAN (16-780): 0: 744: 24.48		ASB3_HUMAN (37-219): 1.2e-20: 93.6: 31.25
+	Hs
		1041153 CUL1_HUMAN (11-780): 0: 748: 27.84		ASB2_HUMAN (72-254): 4e-10: 62.4: 28.34
+	Hs
		1043172 CUL4A_HUMAN (16-780): 0: 744: 24.48		ASB2_HUMAN (72-254): 4e-10: 62.4: 28.34